{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T02:32:08Z","timestamp":1700620328617},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T00:00:00Z","timestamp":1242777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast cancer is a leading cause of death in many countries worldwide and breast lesions remain a common diagnostic dilemma. Fine\u2010needle aspiration biopsy (FNAB) has been suggested as the most important, first line, minimally invasive measure in the management of patients with breast lesions. The aim of this study is to evaluate the efficacy of FNAB in patients with breast lesions by comparing the diagnostic accuracy of cytology results with that of the definitive histological examination outcome and also to investigate the added value of a single aspirator experience to the overall diagnostic precision and compared with the internationally published results. A retrospective study of 303 breast FNAB samples were carried out by a single experienced cytopathologist with complete comparison records.<\/jats:p><jats:p>The prevalence of positive cytologic diagnosis for the breast cancer was determined to be 20.4%. The overall diagnostic accuracy of FNAB was 97.9%, with a specificity and sensitivity of 98.3 and 96.5%, respectively. The overall positive and negative predictive values were determined to be 93.2 and 99.2%, respectively. In addition, the sensitivity was comparable in cases that have been attempted by palpation\u2010guided sampling compared with those aspirations that were carried out under US guidance.<\/jats:p><jats:p>Results from this study confirm that FNAB biopsies performed and reported by a dedicated, single, skilled cytopathologist are highly effective in diagnosis of breast lesions and reliable in differentiating benign and malignant breast lesions with an overall high efficacy in a specialized laboratory\u2010based FNAB clinic. Diagn. Cytopathol. 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21074","type":"journal-article","created":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T15:36:19Z","timestamp":1242833779000},"page":"636-640","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of fine\u2010needle aspiration biopsy in diagnosis of breast cancer: A retrospective study of 303 cases in Bahrain"],"prefix":"10.1002","volume":"37","author":[{"given":"Khalid","family":"Al\u2010Sindi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahid","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal","family":"Golbahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00610.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/clon.2000.9144"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7438.507"},{"key":"e_1_2_1_5_2","first-page":"69","volume-title":"Cytopathology","author":"Powers CN","year":"1996"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1997.8682086.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0956-5507.2003.00084.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21059"},{"key":"e_1_2_1_9_2","first-page":"898","article-title":"The spectrum of the \u2018gray zone\u2019 in breast cytology. A review of 186 cases of atypical and suspicious cytology","volume":"38","author":"al\u2010Kaisi N","year":"1994","journal-title":"Acta Cytol"},{"key":"e_1_2_1_10_2","first-page":"9","article-title":"Atypia in fine needle aspiration cytology of nonpalpable and palpable mammographically detected breast lesions","volume":"38","author":"Mulford DK","year":"1994","journal-title":"Acta Cytol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4741.1996.tb00102.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9040"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<499::AID-CNCR2820350231>3.0.CO;2-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9040"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861001)58:7<1493::AID-CNCR2820580720>3.0.CO;2-F"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3 <671::AID-CNCR2820531313>3.0.CO;2-A"},{"key":"e_1_2_1_17_2","first-page":"11","article-title":"Breast lesions: Diagnosis by fine needle aspiration biopsy","volume":"1","author":"Kline TS","year":"1979","journal-title":"Am J Diagn Gynecol Obstet"},{"key":"e_1_2_1_18_2","first-page":"54","article-title":"Fine needle aspiration cytology of the breast: An overview","volume":"12","author":"Naylor B","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_1_19_2","first-page":"370","article-title":"Cytologic diagnosis of mammary tumors from aspiration biopsy smears: Comparison of cytologic and histologic findings in 2,111 lesions and diagnostic use of cytophotometry","volume":"14","author":"Zajicek J","year":"1970","journal-title":"Acta Cytol"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T20:29:03Z","timestamp":1699907343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,20]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1002\/dc.21074"],"URL":"https:\/\/doi.org\/10.1002\/dc.21074","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,20]]}}}