{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:58:15Z","timestamp":1761580695415},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,6,12]],"date-time":"2009-06-12T00:00:00Z","timestamp":1244764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal medullary carcinoma (RMC) is a rare and aggressive malignant epithelial neoplasm of the kidney. It almost exclusively affects children and young adults with a sickle cell trait or sickle cell disease. The majority of RMC patients present with widely disseminated disease at the time of diagnosis. Herein, we report two cases of young African\u2010American patients with history of sickle cell trait, hematuria and renal mass, who present with malignant right pleural effusions. The cytology of pleural effusion reveals predominantly clusters and individual tumor cells. The tumor cells show high nuclear to cytoplasmic (NC) ratios and large nuclei with nuclear pleomorphism, nuclear grooves, and prominent single or multiple nucleoli. The cytoplasm is dense with a vacuolated and two\u2010tone appearance. Surgical specimens of renal mass and lymph node show features of RMC.<\/jats:p><jats:p>Metastatic RMC to the serous cavity is rare and may present a diagnostic dilemma since it may mimic a poorly differentiated adenocarcinoma or other high\u2010grade malignant neoplasms. RMC should be considered in the differential diagnosis in young patients with a renal mass, particularly in those with history of sickle cell trait or sickle cell disease. Diagn. Cytopathol. 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21111","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T18:23:56Z","timestamp":1245090236000},"page":"843-848","source":"Crossref","is-referenced-by-count":15,"title":["Cytology of metastatic renal medullary carcinoma in pleural effusion: A study of two cases"],"prefix":"10.1002","volume":"37","author":[{"given":"Carla L.","family":"Ellis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Burroughs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire W.","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing Kay","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,6,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199501000-00001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800934"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199912)33:6<551::AID-MPO5>3.0.CO;2-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033737"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<128::AID-CNCR18>3.0.CO;2-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199802000-00017"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02154-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.5858\/2002-126-0627-PQCGHI","article-title":"Pathologic quiz case","volume":"126","author":"Hoenig JD","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.5858\/2000-124-1561-PQC","article-title":"Pathologic quiz case","volume":"124","author":"Mathur SC","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.5858\/2003-127-e135-RMCARO","article-title":"Renal medullary carcinoma: A report of 2 cases and review of the literature","volume":"127","author":"Dimashkieh H","year":"2003","journal-title":"Arch Pathol lab Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199804)18:4<276::AID-DC5>3.0.CO;2-A"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20764"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328296"},{"key":"e_1_2_1_15_2","first-page":"80","volume-title":"Cytology: Diagnostic principles and clinical correlates","author":"French CA","year":"2003"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850701)56:1<200::AID-CNCR2820560134>3.0.CO;2-L"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840130105"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840130406"},{"key":"e_1_2_1_19_2","first-page":"54","article-title":"Collecting duct carcinoma of the kidney","volume":"15","author":"Srigley JR","year":"1998","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199908)21:2<81::AID-DC2>3.0.CO;2-A"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840070111"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20049"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.44"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T03:14:00Z","timestamp":1699931640000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,12]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/dc.21111"],"URL":"https:\/\/doi.org\/10.1002\/dc.21111","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,12]]}}}