{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:02:46Z","timestamp":1778961766192,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T00:00:00Z","timestamp":1254873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liquid\u2010based cytology continues to be utilized as an adjunct to conventional cytology in most Australian laboratories, even though a direct\u2010to\u2010vial ThinPrep protocol has been introduced in many countries with established cervical screening programs. Manual screening of ThinPrep slides has been widely practiced for more than 10 years and the recent introduction of the ThinPrep Imaging System (TPI) has been reported as being more sensitive than the conventional smear (CS) in the identification of high\u2010grade cervical disease.<\/jats:p><jats:p>We report our experience with ThinPrep Imaging since its introduction into our routine gynecological cytology service. 87,284 split sample pairs reported using the Imaging System demonstrated a decrease in unsatisfactory reports (3.65% for CS and 0.87% for TPI) and an increase in possible high grade and definite high\u2010grade squamous reports (1.57% for CS and 1.62% for TPI).<\/jats:p><jats:p>For 1,083 biopsy confirmed high\u2010grade lesions, the correct diagnosis of high grade or possible high\u2010grade squamous disease was made on the ThinPrep imaged slide in 61.0% (661\/1,083) of cases and on the CS in 59.4% (643\/1,083). This was not statistically significant. When all abnormalities identified on cytology were considered, including possible low grade and definite low\u2010grade abnormalities, the difference in sensitivity for Thinprep imaged slides of 96.0% (1,040\/1,083) and CSs of 91.6% (992\/1,083) was statistically significant. Diagn. Cytopathol. 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21199","type":"journal-article","created":{"date-parts":[[2009,10,7]],"date-time":"2009-10-07T19:36:04Z","timestamp":1254944164000},"page":"318-326","source":"Crossref","is-referenced-by-count":38,"title":["Comparison of the sensitivity of conventional cytology and the ThinPrep Imaging System for 1,083 biopsy confirmed high\u2010grade squamous lesions"],"prefix":"10.1002","volume":"38","author":[{"given":"J. A.","family":"Halford","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Batty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Boost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Duhig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1309\/AGB1MJ9H5N43MEGX"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325959"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.07.025"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20627"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-4-6"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20779"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39219.645475.55"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20600"},{"key":"e_1_2_1_11_2","unstructured":"National Pathology Accreditation Advisory Council Performance measures for Australian laboratories reporting cervical cytology. Canberra Australia: National Pathology Accreditation Advisory Council Australian Government Department of Health and Aging;2006."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21069"},{"key":"e_1_2_1_13_2","first-page":"337","article-title":"High\u2010grade squamous intraepithelial lesions and invasive carcinoma following the report of three negative papanicolaou smears: Screening failures or rapid progression?","volume":"5","author":"Sherman ME","year":"1992","journal-title":"Mod Pathol"},{"key":"e_1_2_1_14_2","first-page":"711","article-title":"Characteristics of false\u2010negative smears tested in the normal screening situation","volume":"36","author":"Bosch MMC","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_1_15_2","first-page":"1043","article-title":"False\u2010negative results in cervical cytologic studies","volume":"29","author":"Gay JD","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.1995.tb00484.x"},{"key":"e_1_2_1_17_2","first-page":"4.6","volume-title":"operator's manual: Reproducing a ThinPrep Pap test vial following an unsatisfactory result","author":"Thinprep","year":"2000"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20689"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.05.061"},{"key":"e_1_2_1_20_2","unstructured":"StockT FranklinL.The implementation of the ThinPrep MultiCyte System in a regional cytology laboratory. Poster presentation Australian Society of Cytology Annual Business and Scientific Meeting Sydney 2008."}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21199","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:20:27Z","timestamp":1700608827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,14]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/dc.21199"],"URL":"https:\/\/doi.org\/10.1002\/dc.21199","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,14]]}}}