{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:32:18Z","timestamp":1764783138627},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T00:00:00Z","timestamp":1255996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The gold standard to determine the cause of primary hyperparathyroidism (PHPT) is bilateral neck exploration. As most cases are caused by parathyroid adenoma, there is a movement toward preoperative localization of the abnormal gland by ultrasound and\/or Tc<jats:sup>99<\/jats:sup>\u2010sestamibi scan and minimally invasive parathyroidectomy. Nonpalpable thyroid nodules are common and cannot be differentiated from parathyroid lesions by imaging alone. This study examines cytopathologist\u2010performed ultrasound\u2010guided fine\u2010needle aspiration (UG\u2010FNA) in diagnosis of parathyroid lesions. Between January 1, 2007 and December 31, 2008, seven patients with PHPT or other parathyroid lesions with one or more sonographically\u2010visible thyroid masses underwent cytopathologist\u2010performed UG\u2010FNA with immediate cytological evaluation (ICE). One mass was palpable and nine were nonpalpable. Three parathyroid adenomas, two benign colloid nodules, one papillary carcinoma, three parathyroid cysts, and one thyroid cyst were diagnosed. The nodules in three patients with parathyroid adenomas were identified as follicular lesion\/neoplasm on ICE. Additional UG\u2010FNA passes were made to obtain tissue for immunohistochemistry stains, which confirmed parathyroid origin. Two of these patients had a separate benign colloid nodule and one had a thyroid cyst diagnosed by UG\u2010FNA. The PHPT patient with papillary carcinoma on UG\u2010FNA had the malignancy confirmed at surgery and a sonographically occult parathyroid adenoma. The three patients with thyroid cysts identified by radiology were suspected of being parathyroid cysts on the basis of real\u2010time sonographic features at the biopsy table. The clear cyst fluid obtained by UG\u2010FNA had markedly elevated PTH. Cytopathologist\u2010performed UG\u2010FNA can distinguish between parathyroid and thyroid nodules in patients with suspected parathyroid lesions. Diagn. Cytopathol. 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21203","type":"journal-article","created":{"date-parts":[[2009,10,20]],"date-time":"2009-10-20T21:06:52Z","timestamp":1256072812000},"page":"327-332","source":"Crossref","is-referenced-by-count":31,"title":["Cytopathologist\u2010performed ultrasound\u2010guided fine\u2010needle aspiration of parathyroid lesions"],"prefix":"10.1002","volume":"38","author":[{"given":"David","family":"Lieu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,14]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"176","volume-title":"Henry's clinical diagnosis and management by laboratory methods","author":"McPherson RA","year":"2007"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.3.1024"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-7404(03)00041-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1996.tb00402.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20275"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0182"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010280"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22576"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20800"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.1055"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-3-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326305"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23252"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.4.333"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20783"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.09.038"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.08.030"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:20:04Z","timestamp":1700608804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,14]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/dc.21203"],"URL":"https:\/\/doi.org\/10.1002\/dc.21203","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2010,4,14]]}}}