{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:35:23Z","timestamp":1770824123861,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T00:00:00Z","timestamp":1257379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010risk human papillomavirus (HR\u2010HPV) testing for colposcopy triage of low grade squamous intraepithelial lesion (LSIL) is not recommended because of high positive rates in young women. It remains unclear whether HR\u2010HPV testing may be useful for triage of older women. We compiled HR\u2010HPV data for women aged \u226530 years with LSIL for the period March 1, 2006 to February 28, 2008. Follow\u2010up cervical biopsy information was collected for the period March 1, 2006 to August 15, 2008. We used the Hybrid Capture II test performed on residual material from liquid\u2010based Pap tests. Of 735 women, 254 had HR\u2010HPV testing, and of these 144 had positive HR\u2010HPV results. Among women with positive HR\u2010HPV results 79 underwent biopsy (54.9%) and 11 had cervical intraepithelial neoplasia (CIN) 2 or 3 (13.9% of women with biopsy follow\u2010up). A total of 481 women did not undergo HR\u2010HPV testing, of whom 192 underwent biopsy (39.9%) and 11 had CIN 2 or 3 (5.7% of biopsied women [P = 0.04]). Among women who tested negative for HR\u2010HPV and had follow\u2010up biopsies, only one had a high grade lesion found (CIN 2). The overall HR\u2010HPV positive rate in tested women \u226530 years old with LSIL was 56.7% if women who had reflex HR\u2010HPV testing for ASC\u2010US are included. The HR\u2010HPV positive rate in residual material from Pap tests interpreted as LSIL was 63.8%. Among women \u226530 years of age with LSIL, CIN 2\u20103 is significantly more likely in HR\u2010HPV positive women. Relatively few older women with LSIL test positive for HR\u2010HPV. Colposcopy triage using HR\u2010HPV may be justified in this population. Diagn. Cytopathol. 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21209","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T22:05:03Z","timestamp":1257458703000},"page":"407-412","source":"Crossref","is-referenced-by-count":15,"title":["Women \u226530 years of age with low grade squamous intraepithelial lesion (LSIL) have low positivity rates when cotested for high\u2010risk human papillomavirus: Should we reconsider HPV triage for LSIL in older women?"],"prefix":"10.1002","volume":"38","author":[{"given":"Michael J.","family":"Thrall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina R.","family":"Mody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000109426.82624.f8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.4.293"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.5.397"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328554"},{"key":"e_1_2_1_7_2","unstructured":"VassarStats. 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