{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:30:35Z","timestamp":1788892235454,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:00:00Z","timestamp":1258588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cystadenocarcinoma is a rare malignant tumor, with an estimated incidence of 2% of malignant salivary gland tumors. Cytological diagnosis of cystadenocarcinoma is important for differential diagnosis between benign lesions and malignant tumors with cystic growth. We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23\u2010year\u2010old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 \u00d7 35 mm in diameter. Preoperative fine\u2010needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball\u2010like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap\u2010bubble appearance in the cytoplasm. The papillary\u2010cystic variant of acinic cell carcinoma (ACC\u2010PCV) was suggested from these findings on FNAC. Histologically, the tumor was not encapsulated, but formed large cystic spaces against a background of fibrous connective tissue. The tumor cells in the cystic dilated duct showed papillary structures, which were continuous with the lining cuboidal cells. There was neither a definite double\u2010layered arrangement in cystic ducts and solid islands nor histological findings characteristic of the papillary\u2010cystic or follicular pattern of ACC\u2010PCV. As tumor cells with a small vacuolated, soap\u2010bubble appearance of the cytoplasm are common findings of both cystadenocarcinoma and ACC\u2010PCV, they are of little use for differentiation; however, they are so characteristic that the majority of benign salivary gland lesions with cystic structures can be excluded, if enough attention is paid. Diagn. Cytopathol. 2010. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21232","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T19:45:50Z","timestamp":1258659950000},"page":"377-381","source":"Crossref","is-referenced-by-count":21,"title":["Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review"],"prefix":"10.1002","volume":"38","author":[{"given":"Akihiko","family":"Kawahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Mihashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Akiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Kage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,4,14]]},"reference":[{"key":"e_1_2_1_2_2","series-title":"Atlas of tumor pathology series","doi-asserted-by":"crossref","first-page":"281","DOI":"10.55418\/9781933477442","volume-title":"Tumour of the salivary glands","author":"Ellis GL","year":"2008"},{"key":"e_1_2_1_3_2","first-page":"232","volume-title":"World Health Organization classification of tumours. Pathology and genetics of head and neck tumours","author":"Barnes L","year":"2005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199612000-00002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2004.10.010"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(01)00121-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.08.027"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.01.023"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2006.07.010"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10168"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10110"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199810)19:4<244::AID-DC3>3.0.CO;2-A"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20971"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325978"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10167"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327872"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2005.03.018"},{"key":"e_1_2_1_18_2","first-page":"460","article-title":"Papillary cystadenoma and cystadenocarcinoma of salivary glands: Two unusual entities","volume":"13","author":"Gallego L","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/0019-509X.12352","article-title":"Isolated submandibular gland metastasis from an occult papillary thyroid cancer","volume":"41","author":"Sarda AK","year":"2004","journal-title":"Indian J Cancer"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02728.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00049-5"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02040.x"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21232","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:20:36Z","timestamp":1700608836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,14]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/dc.21232"],"URL":"https:\/\/doi.org\/10.1002\/dc.21232","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,14]]}}}