{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:29:08Z","timestamp":1771302548843,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T00:00:00Z","timestamp":1262908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to evaluate the frequency and the significance of cytomorphological criteria defined in studies as being predictive of neoplasia in cervical smears of women with a cytological diagnosis of atypical glandular cells (AGC) or adenocarcinoma in situ (AIS). Women (<jats:italic>n<\/jats:italic> = 103) with cytological findings suggestive of AGC or AIS, whose diagnoses were later established by histopathology, were included in the study. The criteria analyzed and classified as present or absent in cervical smears previously classified as AGC\u2010NOS (not otherwise specified), AGC\u2010FN (favor neoplasia), or AIS were as follows: irregular nuclear membranes; scanty cytoplasm; dyskeratotic cells; increased nuclear\/cytoplasmic ratio; nucleoli; overlapping; papillary clusters, feathering; loss of polarity; nuclear enlargement; coarsely granular chromatin; and pseudostratified strips. Histopathology resulted in neoplastic diagnoses in 55 cases (53.3%) and nonneoplastic diagnoses in 48 cases (46.6%). Coarsely granular chromatin was observed in 62.5% of cases with a diagnosis of neoplasia. Feathering was present in 80% of cases of histopathological AIS. Loss of polarity and coarsely granular chromatin were significantly associated with neoplastic diagnosis considering all subcategories of glandular abnormalities diagnosis. In AGC\u2010SOE subclassification, coarsely granular chromatin was significantly associated with neoplastic diagnosis. The presence of nucleoli was significantly associated with neoplastic diagnosis in cervical smears qualified as AGC\u2010FN and AIS. Nuclear enlargement, increased nuclear\/cytoplasmic ratio, coarsely granular chromatin and overlapping cells were found in all the subclassifications of glandular cell abnormalities irrespective of the histopathological results. Chromatin aspects, polarity, and presence of nucleoli can predict neoplasia. Diagn. Cytopathol. 2010;38:806\u2010810. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21295","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T21:20:50Z","timestamp":1262985650000},"page":"806-810","source":"Crossref","is-referenced-by-count":7,"title":["Cytomorphological criteria, subclassifications of endocervical glandular cell abnormalities, and histopathological outcome: A frequency study"],"prefix":"10.1002","volume":"38","author":[{"given":"Letisa Comparin Dalla","family":"Nora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinara Zago Silveira","family":"\u00c1zara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelinne Leonel","family":"de Sousa Pace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssio Melo","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos","family":"Zeferino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"do Amaral Westin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie Fran\u00e7oise","family":"Derchain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Helena","family":"Rabelo\u2010Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"123","volume-title":"Sistema Bethesda para citopatologia cervicovaginal, 2a Edi\u00e7\u00e3o","author":"Covell JL","year":"2004"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.OGX.0000070068.74408.F6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2007.00466.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11826"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325384"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10316"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.08.017"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2005.00300.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2001.16.2.214"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10070"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10278"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2003.01020.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328530"},{"key":"e_1_2_5_16_2","first-page":"101","article-title":"Endocervical glandular atypia in Papanicolaou smears","volume":"79","author":"Goff BA","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.08.029"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(200006)22:6<342::AID-DC3>3.0.CO;2-0"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/101.6.708"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.4.403"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00568.x"},{"key":"e_1_2_5_22_2","first-page":"689","article-title":"Cytologic features of high grade squamous intraepithelial lesions involving endocervical glands on thin\u2010layer cytology","volume":"49","author":"Selvaggi SM","year":"2005","journal-title":"Acta Cytol"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21295","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T02:22:50Z","timestamp":1700619770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,8]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1002\/dc.21295"],"URL":"https:\/\/doi.org\/10.1002\/dc.21295","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,8]]}}}