{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:31:26Z","timestamp":1789767086578,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:00:00Z","timestamp":1297382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A variety of malignant spindle\u2010cell tumors are known to occur in the breast, which are collectively referred to as \u201cbreast spindle\u2010cell tumors.\u201d Their interpretation on fine\u2010needle aspiration cytology (FNAC) can be highly tricky. Here, we report a case.<\/jats:p><jats:p>A 47\u2010year\u2010old female presented with a hard, mobile lump in the right breast for 4 months. Five years previous to this, she was treated with radiotherapy for squamous\u2010cell carcinoma (SCC) of cervix. FNA of the breast lump showed high\u2010cell yield with clusters, fascicles, and dissociated cells displaying spindle\u2010cell morphology, with marked pleomorphism, many bizarre uninucleate\/multinucleate giant cells, and a striking mitotic activity. At places, the cells in a necrotic background simulated keratinized squamous cells. Considering the past history of SCC of cervix, the first possibility of metastatic SCC with a differential diagnosis of metaplastic carcinoma, malignant phylloides, and a primary sarcoma of the breast was considered. Subsequent trucut\/excision biopsy with appropriate immunomarkers revealed it to be a case of primary stromal sarcoma ofthe breast with malignant fibrous histiocytoma (MFH)\u2010like features.<\/jats:p><jats:p>Malignant spindle\u2010cell tumor of breast in a patient with SCC of cervix (which also has a tendency to manifest with spindle cell morphology) can cause genuine diagnostic difficulty. In such patients, use of appropriate panel of markers is mandatory for distinguishing between the metastatic SCC from cervix and other more commonly occurring spindle\u2010cell malignancies of the breast. Diagn. Cytopathol.2011;39:223\u2013228. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21407","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T03:33:50Z","timestamp":1278473630000},"page":"223-228","source":"Crossref","is-referenced-by-count":4,"title":["Primary stromal sarcoma of breast with malignant fibrous histiocytoma\u2010like features causing diagnostic dilemma on fine\u2010needle aspiration cytology in a patient with squamous cell carcinoma of cervix: A case report"],"prefix":"10.1002","volume":"39","author":[{"given":"Priyavadhana Rajan","family":"Prasad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debdatta","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelaiah","family":"Siddaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-1-13"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000332686"},{"key":"e_1_2_5_4_2","first-page":"114","article-title":"Primary squamous cell carcinoma of the breast: A case report and review of the literature","volume":"37","author":"G\u00fcrsel B","year":"2007","journal-title":"Turkish J Cancer"},{"key":"e_1_2_5_5_2","first-page":"1523","volume-title":"Rosai and Ackerman's surgical pathology","author":"Rosai J","year":"2004"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-141604208-2.10025-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991225)87:6<359::AID-CNCR7>3.0.CO;2-7"},{"key":"e_1_2_5_8_2","first-page":"270","article-title":"Squamous cell carcinoma of the breast","volume":"47","author":"Pramesh CS","year":"2001","journal-title":"J Postgrad Med"},{"key":"e_1_2_5_9_2","first-page":"1763","volume-title":"Rosai and Ackerman's surgical pathology","author":"Rosai J","year":"2004"},{"key":"e_1_2_5_10_2","first-page":"1474","volume-title":"Diagnostic cytopathology and its histopathologic bases","author":"Bales CE","year":"1992"},{"key":"e_1_2_5_11_2","first-page":"3","volume-title":"Robbins and Cotran pathologic basis of disease","author":"Kumar V","year":"2004"},{"key":"e_1_2_5_12_2","first-page":"372","volume-title":"Manual and atlas of fine needle aspiration cytology","author":"Orell SR","year":"1999"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:41:01Z","timestamp":1700595661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,11]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1002\/dc.21407"],"URL":"https:\/\/doi.org\/10.1002\/dc.21407","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,11]]}}}