{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:04:00Z","timestamp":1700611440691},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T00:00:00Z","timestamp":1282262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leydig cell tumors (LCT) are rare sex cord\u2010stromal tumors that account for 2\u20133% of all testicular tumors. Approximately 10% of LCTs shows evidence of malignant behavior.<\/jats:p><jats:p>We present a case of LCT with severe atypia diagnosed by fine\u2010needle aspiration (FNA) in a 49\u2010year\u2010old man who presented with gynecomastia and right testis enlargement. The FNA material on conventional and ThinPrep smears revealed a hemorrhagic and necrotic background with high cellularity, consisting of large cells, isolated or in small cohesive clusters, abundant, eosinophilic cytoplasm, round nuclei, fine chromatin, and variably conspicuous nucleoli. Occasionally, pleomorphic cells with hyperchromatic nuclei and prominent nucleoli were seen. Immunocytochemistry was positive against vimentin, inhibin, and calretinin. Histological examination of the surgical specimen was in accordance with the FNA findings.<\/jats:p><jats:p>The cytologic diagnosis of LCT of the testis, using FNA, is achievable in a preoperative setting to vitiate the need for more invasive biopsy procedures; malignancy could be considered on cytology when necrosis and marked atypia are evident. Diagn. Cytopathol. 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21446","type":"journal-article","created":{"date-parts":[[2010,8,22]],"date-time":"2010-08-22T22:09:50Z","timestamp":1282514990000},"page":"368-372","source":"Crossref","is-referenced-by-count":5,"title":["Malignant Leydig\u2010cell tumor of the testis diagnosed by fine\u2010needle aspiration using ThinPrep technique"],"prefix":"10.1002","volume":"39","author":[{"given":"Rosalia\u2010Maria","family":"Valeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodoula","family":"Kotakidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Michalakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalambos","family":"Andreadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kokkona","family":"Kousi\u2010Koliakou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charikleia","family":"Destouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.5858\/2007-131-311-AILALC","article-title":"An in\u2010depth look at Leydig cell tumor of testis","volume":"131","author":"Al\u2010Agha OM","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(05)70099-9"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840070610"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199703)16:3<262::AID-DC14>3.0.CO;2-J"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64533-6"},{"key":"e_1_2_4_7_2","first-page":"252","article-title":"Intranuclear Reinke's crystals in a testicular Leydig cell tumor diagnosed by aspiration cytology: A case report","volume":"38","author":"Gupta SK","year":"1994","journal-title":"Acta Cytol"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-e65-CIORCI"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2029"},{"key":"e_1_2_4_10_2","first-page":"199","article-title":"Fine needle aspiration of interstitial\u2010cell tumor of the testis","volume":"31","author":"Crucioli V","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840060306"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199903)20:3<178::AID-DC14>3.0.CO;2-D"},{"key":"e_1_2_4_13_2","first-page":"624","article-title":"Fine needle aspiration of metastatic malignant Leydig cell tumor of the testis; a case report","volume":"50","author":"Naik R","year":"2007","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325317"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199811000-00006"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199805000-00013"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325890"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21446","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:39:09Z","timestamp":1700595549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,20]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1002\/dc.21446"],"URL":"https:\/\/doi.org\/10.1002\/dc.21446","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,20]]}}}