{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:07:23Z","timestamp":1748851643151},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T00:00:00Z","timestamp":1290902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fine needle aspiration, an accepted minimally invasive diagnostic procedure for breast masses, leads to an indeterminate (borderline) diagnosis in a significant proportion of cases. This study was aimed at evaluation of the utility of image analysis and morphometry in the cytologic assessment of borderline breast cases.<\/jats:p><jats:p>A \u2018study\u2019 group of 45 cases (including fibroadenoma, fibrocystic change and ductal carcinoma) and a \u2018test\u2019 group of 25 cytologically borderline cases were included. Nuclei from each of the groups (nuclei of monolayer sheet of fibroadenoma, naked nuclei of fibroadenoma, ductal cells nuclei of fibrocystic change and nuclei of carcinoma) were manually traced and analyzed using self\u2010written image analysis software. Discriminant analysis was done on the \u2018study\u2019 group and the resultant discriminant functions were applied to the \u2018test\u2019 group. The percentage of nuclei correctly classified of the study as well as test group was noted.<\/jats:p><jats:p>On step\u2010wise discriminant analysis, various morphometric, textural parameters and color information parameters were selected. Of the original \u2018study\u2019 group, 98.49% of nuclei could be correctly classified. No overlapping of benign and malignant nuclei was observed in the \u2018study\u2019 group. When the resulting functions were tested on the \u2018test\u2019 group, all the cases were correctly classified as benign or malignant (compared with the final histologic diagnosis).<\/jats:p><jats:p>This study suggests that application of computerized image analysis to cytologically borderline breast cases can help in the classification of these cases as benign or malignant. This may prevent unnecessary surgery in many of these cases. Diagn. Cytopathol. 2012. \u00a9 2010 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21522","type":"journal-article","created":{"date-parts":[[2010,11,28]],"date-time":"2010-11-28T13:48:27Z","timestamp":1290952107000},"page":"191-196","source":"Crossref","is-referenced-by-count":5,"title":["Role of morphometry in evaluation of cytologically borderline breast lesions: A study of 70 cases"],"prefix":"10.1002","volume":"40","author":[{"given":"Shilpa","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchika","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sompal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charan Jeet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,28]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"126","article-title":"Atypia in fine needle aspiration cytology of the breast: A histologic follow\u2010up study of 301 cases","volume":"6","author":"Peterson JL","year":"1989","journal-title":"Semin Diagn Pathol"},{"issue":"1","key":"e_1_2_5_3_2","first-page":"179","article-title":"Application of image analysis to the evaluation of cellular prognostic factors in breast carcinoma","volume":"28","author":"Bacus SS","year":"1993","journal-title":"Pathol Annu"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930815)72:4<1239::AID-CNCR2820720417>3.0.CO;2-Q"},{"key":"e_1_2_5_5_2","first-page":"10","article-title":"Contextual analysis complements single cell analysis in the diagnosis of breast cancer in fine needle aspirates","volume":"10","author":"Detweiler R","year":"1988","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970425)81:2<129::AID-CNCR7>3.0.CO;2-N"},{"key":"e_1_2_5_7_2","first-page":"130","volume-title":"Manual and atlas of fine needle aspiration cytology","author":"Orell SR","year":"1992"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3 <671::AID-CNCR2820531313>3.0.CO;2-A"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197910)44:4<1458::AID-CNCR2820440440>3.0.CO;2-T"},{"key":"e_1_2_5_10_2","first-page":"370","article-title":"Cytologic diagnosis of mammary tumors from aspiration biopsy smears. 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