{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:45:02Z","timestamp":1760298302125},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T00:00:00Z","timestamp":1289779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have suggested that the sensitivity of the ThinPrep Imaging System (TIS) for high\u2010grade intraepithelial lesion (HSIL) and worse may be decreased at workloads above 100 slides\/day. On the other hand, at a threshold of atypical squamous cells of undetermined significance (ASCUS) and above, sensitivity of the TIS appears to more closely correlated with epithelial cell abnormality (ECA)\u2010adjusted workload (ECA rate \u00d7 actual slides\/day) rather than total workload. We sought to determine if the sensitivity of the TIS for HSIL could also be shown to be correlated with ECA\u2010adjusted workload. The change in sensitivity for HSIL from manual screening to TIS screening consistently correlated negatively with ECA\u2010adjusted workload both in the original Food and Drug Administration trial study and in independent studies available in the literature. Both sources suggest that sensitivity near 100% can be achieved with ECA\u2010adjusted workloads of 5\u20137 slides\/day. For a laboratory with an ECA rate of 10%, this represents a total workload of 50\u201370 slides\/day. We conclude that measuring the ECA\u2010adjusted workload is a valuable method to assess workload for the ThinPrep Imaging System. Diagn. Cytopathol. 2012. \u00a9 2010 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21529","type":"journal-article","created":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T16:41:27Z","timestamp":1289839287000},"page":"201-203","source":"Crossref","is-referenced-by-count":3,"title":["HSIL, epithelial cell abnormality\u2010adjusted workload, and the Thinprep imaging system"],"prefix":"10.1002","volume":"40","author":[{"given":"Andrew A.","family":"Renshaw","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik M.","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,15]]},"reference":[{"key":"e_1_2_5_2_2","article-title":"Controls in quality assessment in gynecologic cytology: a rational approach to workload limits for the ThinPrep Imaging system","author":"Renshaw AA","journal-title":"Diagn Cytopathol"},{"key":"e_1_2_5_3_2","article-title":"Sensitivity and workload for manual and automated gynecologic screening: best current estimates","author":"Renshaw AA","journal-title":"Diagn Cytopathol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1309\/AGB1MJ9H5N43MEGX"},{"key":"e_1_2_5_5_2","volume-title":"ThinPrep Imaging System. Package insert","author":"Cytyc Corporation"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20060"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20065"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23497"},{"key":"e_1_2_5_9_2","unstructured":"ThinPrep Pap test package insert (web page June 2010).www.thinprep.com\/hcp\/thinprep_difference\/clinical_independent_studies\/hsil_clinical_studies.html."}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21529","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:37:01Z","timestamp":1700595421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,15]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1002\/dc.21529"],"URL":"https:\/\/doi.org\/10.1002\/dc.21529","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,15]]}}}