{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:46:56Z","timestamp":1757702816353},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010risk human papillomavirus (HR\u2010HPV) DNA testing has emerged as another testing modality for women with mildly cytologic abnormalities. We conducted a two\u2010year follow\u2010up study of 108 women with mildly abnormal cervical cytology for detection of CIN 2\/3. A cervical swab sample was obtained for HPV genotyping by a HPV blot and histologic follow\u2010up results were correlated with HR\u2010HPV types. Of the 108 cases, 93 (86.1%) were positive for HR\u2010HPV DNA. HPV\u201016 was detected in 45.1% of patients. CIN grade 2 or 3 was confirmed in 25 (23.1%) of the 108 women during the two\u2010year follow\u2010up period. The two\u2010year cumulative incidence rates of CIN 2\/3 were 38.6% (17\/44) among HPV\u201016\u2010 positive women, but only 5.6% among HR\u2010HPV\u2010positive women without HPV\u201016 or HPV\u201018. The sensitivity of a positive HPV\u201016 test for CIN 2\/3 was 68.0%, the specificity was 67.5%. Our results demonstrated that the type\u2010specific HPV\u201016 test increased sensitivity of detecting high\u2010grade cervical dysplasia for women who have mildly cytologic abnormalities. The implication of the present findings is that HPV genotyping may identify women with the greatest risk of high\u2010grade CIN. Diagn. Cytopathol. 2012. \u00a9 2010 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21591","type":"journal-article","created":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T15:51:05Z","timestamp":1301068265000},"page":"673-677","source":"Crossref","is-referenced-by-count":5,"title":["Human papillomavirus genotyping as a predictor of high\u2010grade cervical dysplasia in women with mildly cytologic abnormalities: A two\u2010year follow\u2010up report"],"prefix":"10.1002","volume":"40","author":[{"given":"Lee\u2010Wen","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hun\u2010Shan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok\u2010Min","family":"Seow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.4.293"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00418-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00413-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.lgt.0000192694.85549.3d"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210293271804"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.93"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji187"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(03)00167-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048-891X.2004.14418.x"},{"key":"e_1_2_6_12_2","first-page":"518","article-title":"International Agency for Research on Cancer Multicenter Cervical Cancer Study Group","volume":"348","author":"Munoz N","year":"2003","journal-title":"Epidemiologic classification of human papillomavirus types associated with cervical cancer N Engl J Med"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601024"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1994.04020073.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.0865"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0764"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji186"},{"key":"e_1_2_6_18_2","unstructured":"ASCCP. 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