{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:09:26Z","timestamp":1761718166405},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T00:00:00Z","timestamp":1294272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant effusions because of renal\u2010cell carcinoma (RCC) are an unusual event and occur in patients with papillary and clear cell tumors. We have studied a 65\u2010year\u2010old man who underwent right renal tumorectomy, diagnosed as chromophobe RCC (pT1). After 16 months, the patient presented cough and fever. Positron emission computed tomography demonstrated extensive mediastinal lymphadenopathy. Chest radiograph showed right pleural effusion. The cytological examination of the fluid showed malignant cells. Immunohistochemistry had been performed on primary renal tumor and on cell block of pleural effusion. The renal tumor showed positivity for parvalbumin, cytokeratin (CK) 7, C\u2010kit (CD117), E\u2010cadherin, and RCC marker. The neoplastic cells of pleural effusion showed positive immunohistochemical staining for parvalbumin, RCC marker, pancytokeratin, epithelial membrane antigen, CK7, C\u2010kit (CD117), E\u2010cadherin, and CD10. They were negative for thyroid transcription factor\u20101, CK20, calretinin, CK5, D2\u201040 podoplanin, CDX2, and Wilms' tumor suppressor gene. Malignant effusion secondary to RCC is rare. In several studies, RCC had been the cause of 1\u20132.2% of malignant pleural fluids. Chromophobe RCC tends to be localized into the kidney and to be of nuclear grade 2 at presentation, factors that probably explain its more favorable outlook. In our case, the chromophobe RCC was asymptomatic and was discovered because abdominal pain due to stone in the gallbladder. The tumor had an unusual aggressive clinical behavior. Immunohistochemistry performed on the cell block let to establish the renal origin and the chromophobe histotype of malignant cells found in the pleural fluid. Diagn. Cytopathol. 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21599","type":"journal-article","created":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T22:15:04Z","timestamp":1294352104000},"page":"56-61","source":"Crossref","is-referenced-by-count":5,"title":["Malignant effusion of chromophobe renal\u2010cell carcinoma: Cytological and immunohistochemical findings"],"prefix":"10.1002","volume":"40","author":[{"given":"Pusiol","family":"Teresa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorzi","family":"Maria Grazia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morichetti","family":"Doriana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piscioli","family":"Irene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scialpi","family":"Michele,","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,6]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"85","article-title":"The cytologic diagnosis of malignant neoplasms in pleural and peritoneal effusions","volume":"31","author":"Sears D","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_5_3_2","first-page":"753","article-title":"Identification of types and primary sites of malignant tumors by examination of exfoliated tumor cells in serous fluids. 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