{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:05:25Z","timestamp":1778605525025,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T00:00:00Z","timestamp":1297209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection due to Coccidioides spp., a dimorphic fungal pathogen, usually presents as a chronic pulmonary disease, occasionally with pulmonary nodules. On cytology, large spherules filled with endospores are typically seen. We report an unusual case of coccidioidomycosis in a 39\u2010year\u2010old female from an area nonendemic for Coccidioides and without other known risk factors for infection. Fine\u2010needle aspiration of the patient's cavitary lung lesion revealed Coccidioides spp., which demonstrated atypical delicate septate hyphal forms and chains of conidia, with none of the large spherules typical of Coccidioides spp. Atypical hyphal and other forms of Coccidioides spp. have been reported in several studies, primarily from biopsy or tissue resection specimens. However, this is the first case to our knowledge that the organism has presented solely as conidial and atypical hyphal forms in an aspirated specimen. Pathologists who are unfamiliar with this atypical hyphal formation may misdiagnose the organism as several different fungi, including Aspergillus spp. or Fusarium spp. It is important to differentiate among fungi, as antifungal treatments may vary. Cytologists should be aware of the diverse morphologies demonstrated by Coccidioides spp. and include this organism in their differential diagnosis, even in patients seemingly devoid of pertinent risk factors. Diagn. Cytopathol. 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21613","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T19:53:39Z","timestamp":1297281219000},"page":"163-167","source":"Crossref","is-referenced-by-count":14,"title":["An atypical morphologic presentation of <i>coccidioides<\/i> spp. in fine\u2010needle aspiration of lung"],"prefix":"10.1002","volume":"40","author":[{"given":"Audrey N.","family":"Schuetz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pisapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana S.","family":"Hoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,9]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"3040","volume-title":"Mandell, Douglas, and Bennett's principles and practice of infectious diseases","author":"Galgiani J","year":"2005"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/540562"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e3181585439"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(86)90038-6"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(98)90092-3"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198405000-00009"},{"key":"e_1_2_4_8_2","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1128\/JCM.36.12.3721-3723.1998","article-title":"Misleading manifestations of Coccidioides immitis in vivo","volume":"36","author":"Kaufman L","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_4_9_2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5858\/2006-130-97-UFOISC","article-title":"Unusual forms of immature sporulating Coccidioides immitis diagnosed by fine\u2010needle aspiration biopsy","volume":"130","author":"Ke Y","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/99.5.582"},{"key":"e_1_2_4_11_2","first-page":"295:43","article-title":"Questioning CDC's \u201cSelect Agent\u201d criteria","author":"Fierer J","year":"2002","journal-title":"Science"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681219280000311"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.3.1247-1249.2003"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0508-4"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01445-09"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/516970"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:38:22Z","timestamp":1700595502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,9]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/dc.21613"],"URL":"https:\/\/doi.org\/10.1002\/dc.21613","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,9]]}}}