{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:23:08Z","timestamp":1791397388375,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T00:00:00Z","timestamp":1302048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphoma of different histologic type can occur in the same patient. Here, we describe a 64\u2010year\u2010old male patient with angioimmunoblastic T\u2010cell lymphoma (AITL) who subsequently developed diffuse large B\u2010cell lymphoma (DLBCL). At the time of initial diagnosis, histologic examination of a left inguinal lymph node of the patient and a monoclonal pattern of TCR\u03b2 gene rearrangement showed typical features of AITL, and there was no evidence of a monoclonal B\u2010cell population. Twenty\u2010six months later, he had generalized lymphadenopathy and organs involvement by DLBCL. A monoclonal IgH gene rearrangement proved de novo development of secondary B\u2010cell lymphoma and excluded relapse of a primary composite lymphoma. The in situ hybridization analysis showed Epstein\u2010Barr\u2010encoded RNA (EBER) sporadic positivity in sample collected from AITL but extensive positivity in the immunoblasts collected from DLBCL. Our observation supports the hypothesis that Epstein\u2010Barr virus (EBV) is etiologically related to AITL in this case. Clonal expansion of EBV\u2010associated DLBCL is a secondary event in AITL via EBV infection or reactivation. Diagn. Cytopathol. 2011; \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21641","type":"journal-article","created":{"date-parts":[[2011,4,6]],"date-time":"2011-04-06T17:45:17Z","timestamp":1302111917000},"page":"346-351","source":"Crossref","is-referenced-by-count":21,"title":["Sequential development of diffuse large B\u2010cell lymphoma in a patient with angioimmunoblastic T\u2010cell lymphoma"],"prefix":"10.1002","volume":"40","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Huan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u2010Gui","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.06.012"},{"key":"e_1_2_5_3_2","first-page":"309","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Dogan 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