{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:03:53Z","timestamp":1777525433204,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T00:00:00Z","timestamp":1304640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The performance of the Hybrid Capture 2 (HC2) test for human papilloma virus (HPV) detection depends on the prevalence of infection. However, the current HC2 manufacturer recommended interpretative algorithm is the same for all women. This test, which may be particularly useful in perimenopausal and postmenopausal women given the morphologic complexity of their Pap tests, could be affected by the overall lower prevalence of HPV infection in this age group. We investigated HC2 equivocal and weakly positive HPV tests in women 50 years and older and the detection of high\u2010grade dysplasia (CIN2+) on their follow\u2010up specimens. All HC2 test data from 1,067 consecutive specimens and 85 additional specimens from women \u2265 50\u2010years\u2010old with equivocal and weakly positive HC2 were analyzed. Follow\u2010up specimens from women with HC2 tests within these ranges were reviewed. No CIN2+ was found on follow\u2010up of 49 cases of women \u2265 50 with equivocal or weakly positive HC2 results. The current HC2 algorithm resulted in \u201cpositive\u201d reports in 63% of specimens with initial equivocal HC2 due to retests mostly within the equivocal range. These results suggest that women 50 years and older may benefit from higher HC2 thresholds. The test could also be reported as HC2 values (RLU\/CO) to be interpreted in view of risk factors. Diagn. Cytopathol. 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21710","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T16:54:33Z","timestamp":1304700873000},"page":"708-712","source":"Crossref","is-referenced-by-count":3,"title":["Equivocal and weakly positive hybrid capture 2 tests in women aged 50 and older"],"prefix":"10.1002","volume":"40","author":[{"given":"Christiaan Erik","family":"de Vries","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rulong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian A.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20063"},{"key":"e_1_2_5_3_2","first-page":"1409","article-title":"Clinical management guidelines for obstetricians\u2010gynecologists: Cervical cancer screening","volume":"151","author":"American College of Obstetricians and Gynecologists","year":"2009","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980825)84:4<218::AID-CNCR6>3.0.CO;2-I"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1309\/23WU42WYHV8YAJYU"},{"key":"e_1_2_5_6_2","first-page":"408","article-title":"Postmenopausal squamous atypia: A spectrum including \u201cpseudo\u2010koilocytosis.\u201d","volume":"8","author":"Jovanovic AS","year":"1995","journal-title":"Mod Pathol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22687"},{"key":"e_1_2_5_8_2","first-page":"1","volume-title":"Digene: HC2 HPV DNA Test","author":"Assay Manual","year":"2007"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.6.464"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000715)87:2<221::AID-IJC11>3.0.CO;2-2"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690730"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3181cd6d4b"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9014"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21061"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.5858\/2009-0624-OA.1","article-title":"Significance of high risk papilloma virus DNA detection in women 50 years and older with squamous cell Papanicolaou test abnormalities","volume":"134","author":"Zhao CH","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00896-09"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.011"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/PDM.0b013e31805c99ae"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20093"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326118"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21710","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:40:48Z","timestamp":1697064048000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,6]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/dc.21710"],"URL":"https:\/\/doi.org\/10.1002\/dc.21710","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,6]]}}}