{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:52:33Z","timestamp":1778597553147,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T00:00:00Z","timestamp":1306800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although cytological screening for cervical neoplasia has lowered mortality rates, current screening methods are plagued by sub\u2010optimal sensitivity and\/or specificity. The purpose of this study was to compare the performance of the new CellDetect\u00ae staining technology as a potential screening tool. This initial, non\u2010blinded study, utilized samples are taken at a community\u2010based clinic. The diagnostic results using CellDetect\u00ae were compared with the performance of Pap staining and human papilloma virus (HPV) testing on the same material, as well as the follow\u2010up biopsies. These data were statistically analyzed in terms of sensitivity, specificity, predictive value (N.P.V and P.P.V), and inter\u2010observer agreement. Bi\u2010functional CellDetect\u00ae staining revealed morphological details and tinctorial properties that permitted recognition of neoplasia even at low magnification. Performance\u2010wise, CellDetect\u00ae demonstrated non\u2010inferiority for all statistical parameters to both Pap and HPV tests. Importantly, superior sensitivity compared with Pap staining was observed, as well as higher specificity than HPV testing with near equivalent sensitivity. We conclude that CellDetect\u00ae is a promising approach to early detection of cervical cancer because of its bi\u2010functional capabilities that afford high sensitivity and specificity. The data suggest that this new methodology warrants further and more extensive clinical evaluation. Diagn. Cytopathol. 2012. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21729","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T14:16:36Z","timestamp":1306851396000},"page":"1054-1061","source":"Crossref","is-referenced-by-count":6,"title":["Screening for cervical neoplasia: A community\u2010based trial comparing Pap staining, human papilloma virus testing, and the new bi\u2010functional celldetect\u00ae stain"],"prefix":"10.1002","volume":"40","author":[{"given":"Pavel","family":"Idelevich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don","family":"Kristt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Lew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adi","family":"Elkeles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dov","family":"Terkieltaub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia","family":"Rivkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Bruchim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)40621-6"},{"key":"e_1_2_5_3_2","volume-title":"Atlas of Exfoliative Cytology","author":"Papanicolaou GN","year":"1954"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0095-4543(21)00940-4","article-title":"Cervical cancer screening. 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