{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:51:42Z","timestamp":1771462302023,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T00:00:00Z","timestamp":1326326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was to clarify the nuclear features of \u201ccondensed clusters of stromal cells (EGBD\u2010stromal cells)\u201d and \u201cmetaplastic clumps with irregular protrusions (EGBD\u2010metaplastic cells)\u201d which may be recognized in endometrial glandular and stromal breakdown (EGBD) cases in liquid\u2010based cytologic (LBC) preparations of endometrial brushings. The material consists of cytologic smears of 20 cases of proliferative endometrium (PE), 20 cases of EGBD, and 20 cases of endometrioid adenocarcinoma grade 1 (G1) for which histopathological diagnosis was obtained by endometrial curettage. Nuclear findings were examined in PE cells, EGBD\u2010stromal cells, EGBD\u2010metaplastic cells, and G1 cells, respectively.<\/jats:p><jats:p>It was examined about the following items: (1) Nuclear shape; (2) A long\/minor axis ratio in cell nuclei; (3) An area of cell nuclei; (4) Overlapping nuclei; (5) The distribution pattern of nuclei within cell clusters.<\/jats:p><jats:p>The following observations were made: (1) In PE cells, round\u2010oval nuclei appeared to predominate, overlapping nuclei were not observed, and a slightly abnormal distribution pattern of nuclei was recorded; (2) In EGBD\u2010stromal cells, reniform nuclei were characteristically observed, nuclei had small size and a generally elongated appearance, overlapping nuclei were recognized, and a remarkable abnormal distribution pattern of nuclei was found; (3) In EGBD\u2010metaplastic cells, spindle nuclei were a characteristic feature, nuclei were larger in size and had a bipolar appearance, overlapping nuclei with moderately abnormal distribution pattern of nuclei were identified; (4) In G1 cells round\u2010oval nuclei predominated, overlapping nuclei with moderately abnormal distribution pattern of nuclei were found.<\/jats:p><jats:p>The study demonstrates that the analysis of selected nuclear findings appears to be very useful in the cytopathological assessment of endometrial lesions in LBC samples, especially for the discrimination of EGBD and G1. Diagn. Cytopathol. 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21738","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T12:18:40Z","timestamp":1326370720000},"page":"1077-1082","source":"Crossref","is-referenced-by-count":13,"title":["Nuclear features in endometrial cytology: Comparison of endometrial glandular and stromal breakdown and endometrioid adenocarcinoma grade 1"],"prefix":"10.1002","volume":"40","author":[{"given":"Yoshiaki","family":"Norimatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumie","family":"Shigematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ohsaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yanoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namiki","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao K.","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,12]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.56.2.106"},{"key":"e_1_2_5_3_2","first-page":"913","article-title":"Annual report on cervical, endometrial, and ovarian cancer","volume":"61","author":"Oncology Committee","year":"2007","journal-title":"Acta Obst Gynaec Jpn"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326722"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21734"},{"key":"e_1_2_5_6_2","first-page":"431","volume-title":"Blaustein's pathology of the female genital tract","author":"Sherman ME","year":"2001"},{"key":"e_1_2_5_7_2","first-page":"463","article-title":"Atypical cells and stromal breakdown two case reports","volume":"19","author":"Ehrmann RL","year":"1975","journal-title":"Acta Cytol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20524"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20512"},{"key":"e_1_2_5_10_2","first-page":"737","volume-title":"Diagnostic cytopathology","author":"Kobayashi TK","year":"2010"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21141"},{"key":"e_1_2_5_12_2","volume-title":"PrepStain\u2122 slide processor operator's manual 780\u201313000\u201000 Rev. 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