{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:16:31Z","timestamp":1784740591570,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:00:00Z","timestamp":1318291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Large three\u2010dimensional cell aggregates and psammoma bodies are usually encountered in benign serous effusions (mesothelial hyperplasia and endosalpingiosis), mesotheliomas, and metastatic papillary carcinomas. We report a case of pulmonary small\u2010cell carcinoma occurring in an 88\u2010year\u2010old woman that initially presented with a malignant pleural effusion characterized cytologically by a predominance of large three\u2010dimensional neoplastic cell aggregates (\u201ccannonballs\u201d), associated with rare psammoma bodies. Although the crowded three\u2010dimensional tumor\u2010cell aggregates did not allow detailed cytologic examination, the diagnosis of metastatic small\u2010cell carcinoma could be established noting the characteristic chromatin features of the occasional single neoplastic cells and the characteristic \u201ccell\u2010in\u2010cell\u201d and \u201cstack\u2010of\u2010coins\u201d arrangements of rare small clusters of neoplastic cells. Immunoperoxidase stains showing positivity of the tumor cells for CD56, synaptophysin, and TTF1 further supported this diagnosis. Endobronchial ultrasound\u2010guided fine\u2010needle aspiration of a mediastinal lymph node subsequently confirmed the diagnosis of pulmonary small\u2010cell carcinoma. Metastatic pulmonary small\u2010cell carcinoma should be considered in the differential diagnosis of serous effusions showing large three\u2010dimensional neoplastic cell aggregates and psammoma bodies to prevent a potential diagnostic pitfall. Diagn. Cytopathol. 2013. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21770","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T08:10:56Z","timestamp":1318320656000},"page":"247-252","source":"Crossref","is-referenced-by-count":7,"title":["\u201cCannonballs\u201d and psammoma bodies: Unusual cytologic features of metastatic pulmonary small\u2010cell carcinoma in a pleural effusion"],"prefix":"10.1002","volume":"41","author":[{"given":"Andrea B.","family":"Conway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa K.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Jessurun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan E.","family":"Pambuccian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,11]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.12.1091"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pcr.0000204640.01263.d0"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.1.2.118"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.9.1.26"},{"key":"e_1_2_3_6_2","first-page":"525","article-title":"Oat\u2010cell bronchial carcinoma. Identification of cells in pleural fluid","volume":"20","author":"Spriggs AI","year":"1976","journal-title":"Acta Cytol"},{"key":"e_1_2_3_7_2","first-page":"298","article-title":"The unique cytologic picture of oat cell carcinoma in effusions","volume":"20","author":"Salhadin A","year":"1976","journal-title":"Acta Cytol"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200607000-00004"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199808)19:2<131::AID-DC14>3.0.CO;2-G"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20810"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10403"},{"key":"e_1_2_3_12_2","first-page":"321","article-title":"The cytomorphological spectrum of small cell carcinomas and large cell neuroendocrine carcinomas in serous effusion. Our experience with 68 cases","volume":"118","author":"Yang H","year":"2010","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20161"},{"key":"e_1_2_3_14_2","first-page":"327","article-title":"Psammoma bodies in small cell carcinoma of the lung: A case report","volume":"26","author":"Bauer TW","year":"1982","journal-title":"Acta Cytol"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10011"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326641"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.21770","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.21770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T14:31:19Z","timestamp":1697639479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.21770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,11]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1002\/dc.21770"],"URL":"https:\/\/doi.org\/10.1002\/dc.21770","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,11]]}}}