{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:59:16Z","timestamp":1768564756934,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T00:00:00Z","timestamp":1329955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatoblastoma (HB) is classified into epithelial, mixed (epithelial\/mesenchymal), and small\u2010cell (anaplastic) type. Wnt\/\u03b2\u2010catenin pathway plays a key role in hepatic development, regeneration, and tumorigenesis, and HB is known to present \u03b2\u2010catenin mutations (50\u201390%). The present study was undertaken to delineate the cytomorphologic features of HB and to evaluate the feasibility of subtyping of HB on fine\u2010needle aspiration cytology (FNAC). The expression of \u03b2\u2010catenin in these tumors was also evaluated both of histopathologic sections and on the aspirated material. Thirty\u2010three cases with fine\u2010needle aspirates of HB were retrieved over a period of 12 years. Cytologic diagnosis was reviewed in the light of clinicoradiological data, response to therapy, and subsequent histopathology. Immunochemistry for \u03b2\u2010catenin was performed in 19 of 33 cases on histopathologic sections (<jats:italic>n<\/jats:italic> = 10)\/cell blocks (<jats:italic>n<\/jats:italic> = 6)\/cytosmears (<jats:italic>n<\/jats:italic> = 3). Based on the cytologic features, the cases were divided into fetal HB (<jats:italic>n<\/jats:italic> = 17), embryonal HB (<jats:italic>n<\/jats:italic> = 4), combined epithelial HB (<jats:italic>n<\/jats:italic> = 8), and mixed HB (<jats:italic>n<\/jats:italic> = 4). Four cases of histopathologically proven mixed HB were reported as pure epithelial HB on FNAC, as mesenchymal elements were not represented in the cytology smears. Cytoplasmic as well as nuclear staining for \u03b2\u2010catenin was noted in a total of 10 of 19 cases. FNAC can accurately categorize epithelial HB; however, in mixed type, the accuracy depends on number of areas sampled. Cell block can be of help to perform ancillary investigations especially \u03b2\u2010catenin for both diagnostic and therapeutic purposes. Cytopathol. 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21772","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T14:06:38Z","timestamp":1330005998000},"page":"95-101","source":"Crossref","is-referenced-by-count":12,"title":["Hepatoblastoma\u2014An attempt of histological subtyping on fine\u2010needle aspiration material"],"prefix":"10.1002","volume":"41","author":[{"given":"Adarsh","family":"Barwad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalini","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirti","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Rajwanshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram Kumar","family":"Marwaha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. L. N.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranab","family":"Dey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raje","family":"Nijhawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,2,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050845"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198212000-00001"},{"key":"e_1_2_5_4_2","first-page":"141","article-title":"Mesenchymal tumors of the liver. 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