{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T17:02:06Z","timestamp":1743526926373},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:00:00Z","timestamp":1318291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell prolymphocytic leukemia (T\u2010PLL) is a very unusual form of chronic lymphoproliferative disorder, which has rarely been diagnosed by fine needle aspiration (FNA) cytology. We report one such case with some overlapping cytomorphological features with chronic lymphocytic leukemia and acute lymphoblastic leukemia. A 91\u2010year\u2010old man presented with generalized lymphadenopathy, pleural effusion, ascites, and an ulcerated growth in rectum. FNA smears from the left cervical lymph node showed a monotonous population of small lymphoid cells having small but distinct nucleoli that was initially diagnosed as chronic lymphocytic leukemia (CLL). Smears from the left axillary lymph node contained both small and medium\u2010sized lymphoid cells with frequent hand\u2010mirror cell appearance, which has been described in acute lymphoblatic leukemia (ALL). Immunocyto\/histochemical stainings on smears and cell block preparations of the aspirate showed the following immunophenotype: CD3+, CD4+, CD5+, CD7+, CD8\u2010, CD20\u2010, CD23\u2010, and Tdt\u2010. Total peripheral blood leukocyte count was 26.4 \u00d7 10<jats:sup>9<\/jats:sup>\/L and total lymphocyte count, 8.3 \u00d7 10<jats:sup>9<\/jats:sup>\/L with predominance of small lymphocytes. T\u2010cell nature of the neoplasm was confirmed by biopsies from the cervical lymph node (T\u2010cell lymphoma), bone marrow (T\u2010cell lymphoid neoplasm\/chronic lymphocytic leukemia), and the ulcerated rectal lesion (atypical T\u2010cell lymphoproliferative disorder). The patient developed deep vein thrombosis, heparin\u2010induced thrombocytopenia and bleeding from duodenal ulcer. By the time the reports of all the investigations were ready, the patient succumbed to bronchopneumonia. To the best of our knowledge, this T\u2010CLL\/T\u2010PLL which was diagnosed initially by FNA cytology with immunocytochemical support is first of its kind to be reported. Diagn. Cytopathol. 2013;41:360\u2013365. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21781","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T08:00:03Z","timestamp":1318320003000},"page":"360-365","source":"Crossref","is-referenced-by-count":4,"title":["T\u2010cell prolymphocytic leukemia (T\u2010PLL) with overlapping cytomorphological features with T\u2010CLL and T\u2010ALL: A Case Initially Diagnosed by Fine\u2010Needle Aspiration Cytology and Immunocytochemistry"],"prefix":"10.1002","volume":"41","author":[{"given":"Dilip K.","family":"Das","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahed K.","family":"Pathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munish","family":"Joneja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma A.","family":"Al\u2010Musawi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bency","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran R.","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,11]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"164","article-title":"T\u2010small lymphocyte disorders","volume":"36","author":"Bartlett NL","year":"1999","journal-title":"Semin Hematol"},{"issue":"2","key":"e_1_2_4_3_2","first-page":"S46","article-title":"Chronic lymphatic leukemias of T and NK cell type","volume":"11","author":"Kingreen D","year":"1997","journal-title":"Leukemia"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199910)21:4<240::AID-DC3>3.0.CO;2-Z"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200012)23:6<375::AID-DC2>3.0.CO;2-1"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9022"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10185"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10617"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326323"},{"key":"e_1_2_4_10_2","first-page":"591","article-title":"Morphological and functional classification of non\u2010Hodgkin lymphoma: Frequency of distribution of sub\u2010types","volume":"81","author":"Das DK","year":"1985","journal-title":"Indian J Med Res"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008349422735"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.060"},{"key":"e_1_2_4_13_2","first-page":"169","article-title":"True small lymphocytic T\u2010cell chronic lymphocytic leukemia lacking the CD3 molecule and TCR\u2010alpha beta on its cell surface","volume":"70","author":"Murakami K","year":"1999","journal-title":"Int J Hematol"},{"key":"e_1_2_4_14_2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1182\/blood.V86.3.1163.1163","article-title":"True T\u2010cell chronic lymphocytic leukemia: A morphologic and immunophenotypic study of 25 cases","volume":"86","author":"Hoyer JD","year":"1995","journal-title":"Blood"},{"key":"e_1_2_4_15_2","first-page":"775","article-title":"Cellules grumel\u00e9es. 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