{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:46:00Z","timestamp":1744267560006},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,8,26]],"date-time":"2011-08-26T00:00:00Z","timestamp":1314316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to assess the utility of liquid\u2010based cytologic preparation (LP) compared with conventional preparation (CP) for the assessment of nuclear findings in endometrial glandular and stromal breakdown (EGBD) which may be misdiagnosed as carcinoma in EGBD cases. The material consists of cytologic smears including 20 cases of proliferative endometrium (PE), 20 cases of EGBD, and 20 cases of endometrioid adenocarcinoma grade1 (G1) for which histopathological diagnosis was obtained by endometrial curettage at the JA Suzuka General Hospital. Nuclear findings were examined in PE cells, EGBD\u2010stromal cells, EGBD\u2010metaplastic cells, and G1 cells, respectively. It was examined about the following items; (1) nuclear shape; (2) A long\/minor axis ratio in cell nuclei; (3) an area of cell nuclei; (4) overlapping nuclei. Results are as follows: (1) nuclear shape; as for the reniform shape of EGBD\u2010stromal cells and spindle shape of EGBD\u2010metaplastic cells, the ratio of the LP method was a higher value than the CP method. (2) The long axis and area of cell nuclei; LP in all groups was a recognizable tendency for nuclear shrinkage. (3) The long\/minor axis ratio in cell nuclei; only EGBD\u2010metaplastic cells recognize a significant difference between CP and LP. (4) Overlapping nuclei; LP was a higher value in comparison with CP in the other groups except PE cells, and the degree of overlapping nuclei was enhanced about three times. Therefore, although a cell of LP has a shrinking tendency, (1) it is excellent that LP preserves a characteristic of nuclear shape than CP; (2) a cellular characteristic becomes clearer, because three\u2010dimensional architecture of LP is preserved of than CP. As for the standard preparation method for endometrial cytology samples, we considered that a concrete introduction of the LP method poses no problems. Diagn. Cytopathol. 2013. \u00a9 2011 Wiley Periodicals, Inc<\/jats:p>","DOI":"10.1002\/dc.21784","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T03:46:39Z","timestamp":1314848799000},"page":"120-125","source":"Crossref","is-referenced-by-count":14,"title":["Nuclear characteristics of the endometrial cytology: Liquid\u2010based versus conventional preparation"],"prefix":"10.1002","volume":"41","author":[{"given":"Yoshiaki","family":"Norimatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumie","family":"Shigematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ohsaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yanoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namiki","family":"Kawanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao K.","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(200001)22:1<52::AID-DC14>3.0.CO;2-#"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20599"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.5.6.857"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.12.012"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326722"},{"key":"e_1_2_5_7_2","first-page":"239","article-title":"Cell surplus on sampling devices after routine cervical cytologic smears: A study of residual cell population","volume":"41","author":"Goodman A","year":"1996","journal-title":"J Reprod Med"},{"key":"e_1_2_5_8_2","first-page":"434","article-title":"Screening errors in cervical cytologic screening","volume":"31","author":"van der Graaf Y","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21734"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2007.05.005"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00589.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20524"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20512"},{"key":"e_1_2_5_14_2","article-title":"Nuclear features of endometrial cytology: With endometrial glandular and stromal breakdown and endometrioid adenocarcinoma grade1","author":"Norimatsu Y","journal-title":"Diagn Cytopathol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20528"},{"key":"e_1_2_5_16_2","volume-title":"PrepStain\u2122 slide processor Operator's manual 780\u201313000\u201000 Rev. 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