{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:05:25Z","timestamp":1760267125812},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:00:00Z","timestamp":1318291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histoplasmosis is usually an opportunistic fungal infection in patients with defective cell mediated immunity, and has been considered as one of the acquired immunodeficiency syndrome (AIDS) defining illness. However, cutaneous involvement in human immunodeficiency virus (HIV) positive patients is less common, and very rarely can be the initial presenting symptom for the diagnosis of AIDS. We present here an unusual case of multiple diffuse cutaneous nodular lesions predominantly in face, trunk, and upper extremities diagnosed initially on aspiration cytology as histoplasmosis. Subsequent serological test revealed positivity for HIV 1 and 2, along with a low CD4 count and low CD4:CD3 ratio. The cytomorphological features were further corroborated by histology and histochemical stains. Hence, cutaneous histoplasmosis can cause multiple wide spread nodular or umbilicated lesions in AIDS patients as the initial presentation. Fine needle aspiration cytology (FNAC) is a rapid, cost effective tool for diagnosis of the fungi from such lesions and initiating work up for immunocompromised states including AIDS. Diagn. Cytopathol. 2013. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21814","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T07:59:53Z","timestamp":1318319993000},"page":"459-462","source":"Crossref","is-referenced-by-count":8,"title":["Cytodiagnosis of cutaneous histoplasmosis in HIV positive patient initially presenting with multiple umbilicated disseminated skin nodules"],"prefix":"10.1002","volume":"41","author":[{"given":"Bandyopadhyay","family":"Arghya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majumdar","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gangopadhyay","family":"Mimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakraborty","family":"Subrata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,11]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027-06"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.71850"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2009.00693.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90075-4"},{"key":"e_1_2_4_6_2","first-page":"19","article-title":"Sudden onset of verrucous plaques to the face and trunk: A case of cutaneous histoplasmosis in the setting of HIV","volume":"14","author":"Friedman A","year":"2008","journal-title":"Dermatol Online J"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-777X.62884"},{"key":"e_1_2_4_8_2","first-page":"94","article-title":"Skin sensitivity to histoplasmin in Calcutta and its neighborhood","volume":"46","author":"Sanyal M","year":"1980","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.32743"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199011000-00004"},{"key":"e_1_2_4_11_2","first-page":"151","article-title":"Primary cutaneous histoplasmosis","volume":"66","author":"Nair PS","year":"2000","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_4_12_2","first-page":"527","article-title":"Disseminated histoplasmosis diagnosed by percutaneous needle biopsy of a retroperitoneal lymph node. 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