{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:28:08Z","timestamp":1773937688880,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T00:00:00Z","timestamp":1317340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aims of this study were to determine the expression of Ki\u201067 in type I and type II endometrial adenocarcinomas as well as normal endometrium in imprint smears and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. During a 29\u2010month period, 255 patients were evaluated with entometrial imprint cytology. Endometrial samples freshly resected from women who underwent total abdominal hysterectomy were studied. One hundred twenty\u2010six patients had endometrial carcinoma and 129 cases were diagnosed as normal endometrium. The expression of Ki\u201067 was assessed by immunocytochemistry. Positive staining was correlated with increased stage, grade and lymph node metastases. High expression was more frequent in type II than type I endometrial adenocarcinoma and high\u2010grade endometrial carcinoma had higher proportions of Ki\u201067 positive immunostaining compared with low\u2010grade carcinoma. Proliferative endometrium showed high Ki\u201067 expression level, even higher than those of grade 1 and type I. On the other hand, secretory endometrium Ki\u201067 positive cells were markedly diminished and even disappeared. Completely negative staining was found to be related to atrophic endometrium. Immunocytochemical findings from Ki\u201067 stain, in addition to cytomorphologic features, appeared to be useful for the diagnosis of endometrial carcinoma in endometrial cytology with imprint smears. High Ki\u201067 expression correlates with morphologic features of aggressiveness and the expression pattern of Ki\u201067 correspond to the expected cyclic\/atrophic pattern in normal endometrium. Diagn. Cytopathol. 2013. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.21825","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T16:45:23Z","timestamp":1317401123000},"page":"212-217","source":"Crossref","is-referenced-by-count":20,"title":["Expression of ki\u201067 as proliferation biomarker in imprint smears of endometrial 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