{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:15:05Z","timestamp":1761988505338},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T00:00:00Z","timestamp":1346371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>The cytologic diagnosis of synovial sarcoma (SS) can be difficult when it occurs in unusual locations, atypical age groups, and\/or have unusual morphology. We report a case of primary mediastinal SS in a 65\u2010year\u2010old male with a long smoking history who presented with increasing shortness of breath and was found to have a 14.2 cm mediastinal mass. Smears from the endobronchial ultrasound guided fine needle aspiration of the mass were moderately cellular consisting of loosely cohesive clusters, some of which demonstrated nuclear molding, and dispersed single cells. The relatively uniform tumor cells had a high nuclear\u2010to\u2010cytoplasmic ratio, finely granular chromatin, and inconspicuous nucleoli. Some of the single cells had spindled morphology with unipolar wispy tails and naked nuclei. Based on the clinical presentation and the cytomorphologic features, our initial differential diagnoses included atypical carcinoid, small cell carcinoma, basaloid squamous cell carcinoma, sarcoma, and lymphoma. Immunohistochemical studies on the cell block sections revealed that the tumor cells were focally positive for cytokeratin and diffusely positive for CD56, while negative for CD45, synaptophysin and chromogranin. Ultimately, an immunohistochemical stain for TLE\u20101 demonstrated diffusely strong nuclear positivity and molecular studies showed the presence of the t(X; 18) SYT\/SSX1 translocation confirming the diagnosis of SS. In this report, we describe the cytomorphologic features of SS, its diagnostic pitfalls, and potential mimics in the mediastinum. Diagn. Cytopathol. 2014;42:170\u2013176. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.22912","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T06:49:27Z","timestamp":1346395767000},"page":"170-176","source":"Crossref","is-referenced-by-count":13,"title":["Fine needle aspiration of primary mediastinal synovial sarcoma: Cytomorphologic, immunohistochemical, and molecular study"],"prefix":"10.1002","volume":"42","author":[{"given":"Cheng Cheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire W.","family":"Michael","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy C.","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198264010-00016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910315)67:6<1667::AID-CNCR2820670631>3.0.CO;2-U"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199903000-00004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930715)72:2<469::AID-CNCR2820720224>3.0.CO;2-Q"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197504)35:4<1243::AID-CNCR2820350432>3.0.CO;2-A"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/77.6.686"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2010.07.006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157934.50936.3e"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800795"},{"key":"e_1_2_5_11_1","first-page":"109","article-title":"Primary mediastinal synovial sarcoma","volume":"76","author":"Jeganathan R","year":"2007","journal-title":"Ulster Med J"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10265"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1996.38782397.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.21130"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000147401.95391.9a"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10188"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.02.011"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.6.769"},{"key":"e_1_2_5_19_1","first-page":"505","article-title":"Fine needle aspiration cytology of pulmonary carcinoid tumors","volume":"34","author":"Anderson C","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_5_20_1","first-page":"183","article-title":"Capillaries. 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