{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:17:21Z","timestamp":1696659441441},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T00:00:00Z","timestamp":1358812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Isolated spinal leptomeningeal metastases (LMM) without brain metastases are infrequent, accounting for about 1% of all solid tumors. In LMM, cerebrospinal fluid (CSF) analyses are mostly abnormal. Demonstrations of intrathecal tumor markers are highly suggestive, but only a positive cytology is diagnostic. The initial CSF cytology can give a false negative result in up to 40\u201350% of patients with pathologically proven LMM on autopsy. We report a case of intrahepatic cholangiocarcinoma with spinal LMM confirmed using cytokeratin7 and pancytokeratin (AE1\/AE3) immunocytochemical studies on paucicellular cerebrospinal fluid cytospin preparation. Given the paucicellularity of the smears and difficult morphologic categorization, immunocytochemistry is vital for confirmatory diagnosis and can help reduce false negative results. To the best of our knowledgethis is the first case report of cytologically confirmed LMM from an intrahepatic cholangiocarcinoma while the patient was undergoing treatment. Diagn. Cytopathol. 2014;42:54\u201357. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.22946","type":"journal-article","created":{"date-parts":[[2013,1,22]],"date-time":"2013-01-22T15:46:08Z","timestamp":1358869568000},"page":"54-57","source":"Crossref","is-referenced-by-count":4,"title":["Utility of immunocytochemistry in diagnosing leptomeningeal metastases from an intrahepatic cholangiocarcinoma"],"prefix":"10.1002","volume":"42","author":[{"given":"Shweta","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Pathology North Shore Long Island Jewish Health System Lake Success New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pathology North Shore Long Island Jewish Health System Lake Success New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhoomi","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Surgery Long Island Jewish Medical Center New Hyde Park New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora J.","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Department of Pathology North Shore Long Island Jewish Health System Lake Success New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-8101-x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.10.1369"},{"key":"e_1_2_4_4_1","first-page":"841","article-title":"leptomeningeal carcinomatosis as presenting symptom of gall bladder carcinoma","volume":"30","author":"Highes\u2010Pascual F","year":"2000","journal-title":"Rev Neurol"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02341153"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.suppl_6.vi1"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005970406557"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380111"},{"key":"e_1_2_4_9_1","first-page":"1175","article-title":"Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma","volume":"33","author":"Lau SK","year":"2002","journal-title":"Ann Neurol"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149708.12335.6a"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000067683.84284.66"},{"key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.5858\/2000-124-0759-DVOIIL","article-title":"Diagnostic value of immunocytochemistry in leptomeningeal tumor dissemination, A report of two cases","volume":"124","author":"Thomas JE","year":"2000","journal-title":"Arch Pathol Lab Med"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.22946","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.22946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T10:10:15Z","timestamp":1696587015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.22946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,22]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1002\/dc.22946"],"URL":"https:\/\/doi.org\/10.1002\/dc.22946","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,22]]}}}