{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:07:08Z","timestamp":1773907628570,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Erdheim\u2010Chester disease (ECD) is a rare, non\u2010Langerhans form of histiocytosis of unknown origin with distinct clinicopathologic and radiographic features. Reports detailing the cytology of ECD are rare. We describe a case of ECD with pericardial effusion. Cytologic examination revealed a hypercellular specimen composed of clusters and singly dispersed foamy macrophages with round nuclei and inconspicuous nucleoli, admixed with lymphocytes, eosinophils, and Touton\u2010type multinucleated giant cells. Immunostains for CD68 were strongly positive in the foamy macrophages while S100 and CD1a were negative. The presence of foamy histiocytes, multinucleated giant cells, lymphocytes and eosinophils are also features of other systemic histiocytic disorders, including Langerhans cell histiocytosis (LCH), Rosai\u2010Dorfman disease (RDD) and sarcoidosis. To the best of out knowledge, this is the first report describing the cytological features of ECD in a pericardial effusion. Diagn. Cytopathol. 2014;42:530\u2013534. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.22957","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T21:03:09Z","timestamp":1362085389000},"page":"530-534","source":"Crossref","is-referenced-by-count":8,"title":["Erdheim\u2010Chester disease with prominent pericardial effusion"],"prefix":"10.1002","volume":"42","author":[{"given":"Borislav A.","family":"Alexiev","sequence":"first","affiliation":[{"name":"Department of Pathology University of Maryland Medical Center Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N.","family":"Staats","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Maryland Medical Center Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834d861d"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880583"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690100900115"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181f2bf06"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.018481"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200208000-00008"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01650.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-294108"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01942684"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2010.01104.x"},{"key":"e_1_2_4_12_1","first-page":"1688","article-title":"Hydropericardium prevented diagnosis of constrictive pericarditis: an unusual case of Rosai\u2010Dorfman disease","author":"Xu J","year":"2009","journal-title":"BMJ Case Rep"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-007-0538-9"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2382041525"},{"key":"e_1_2_4_15_1","first-page":"619","article-title":"Erdheim\u2010Chester disease. 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