{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:37:50Z","timestamp":1697665070724},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>A 58\u2010year\u2010old lady presented with mediastinal lymphadenopathy. A thoracoscopic ultrasound\u2010guided fine\u2010needle aspiration showed large atypical epithelioid cells arranged in cohesive sheets and dispersed as single cells with intact cytoplasm amid a background of lymphocytes and histiocytes. A cytological diagnosis of \u201ca malignant neoplasm\u201d was made, raising a broad list of differential diagnoses. A broad panel of immunocytochemical stains performed on the cell block was indicative of a lymphoproliferative disorder, but the immunophenotype was intermediate between diffuse large B cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL). Diffuse and strong reactivity to CD20, CD79a, and PAX\u20105, and weak reactivity to CD30, was in favor of a DLBCL, or more precisely mediastinal (thymic) large B cell lymphoma (MLBL). However, there were negative staining for LCA, OCT\u20102, and BOB\u20101 as well as positive staining for EBV\u2010encoded RNA, which were against a diagnosis of MLBL and raised the possibility of cHL. The absence of RS cells and the typical mileu, the negativity for CD15 and the strong positivity of CD20 and PAX\u20105 were against a diagnosis of cHL. On this basis, the diagnosis of \u201cB\u2010cell lymphoproliferative disorder with features intermediate between DLBCL and cHL\u201d was rendered. The diagnosis was subsequently confirmed on excisional biopsy. This case report demonstrates broad differential diagnoses raised by this diagnostic entity and the importance of an adequate cell block for accurate designation. Diagn. Cytopathol. 2014;42:690\u2013693. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.22967","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T09:13:12Z","timestamp":1367313192000},"page":"690-693","source":"Crossref","is-referenced-by-count":7,"title":["B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and classical hodgkin lymphoma: Diagnosis by fine\u2010needle aspiration cytology"],"prefix":"10.1002","volume":"42","author":[{"given":"Kyaw","family":"Lynnhtun","sequence":"first","affiliation":[{"name":"Anatomical Pathology Department ICPMR Westmead Hospital Westmead New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winny","family":"Varikatt","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department ICPMR Westmead Hospital Westmead New South Wales Australia"},{"name":"School of Medicine, University of Western Sydney  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmala","family":"Pathmanathan","sequence":"additional","affiliation":[{"name":"Anatomical Pathology Department ICPMR Westmead Hospital Westmead New South Wales Australia"},{"name":"School of Medicine, University of Western Sydney  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10714"},{"key":"e_1_2_4_3_1","first-page":"563","article-title":"Lymph node examination by fine needle aspiration in patients with known or suspected malignancy","volume":"31","author":"Lee RE","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_4_4_1","first-page":"76","article-title":"Fine Needle aspiration biopsy in the diagnosis of lymphadenopathy in 1103 patients. 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