{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:04:41Z","timestamp":1788393881967,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T00:00:00Z","timestamp":1370649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>Atypical squamous cells, cannot exclude high grade squamous intraepithelial lesion (ASC\u2010H) is a recognized category in the 2001 Bethesda Nomenclature System for cervical cytology. Although current ASCCP guidelines recommend colposcopic follow\u2010up, more recent studies are suggesting prior triage for HPV\u2010DNA analysis. We report on our experience at the University of Wisconsin Hospital and Clinics. From January 1, 2003 through December 31, 2011 (9\u2010y), the cytopathology laboratory processed 109,424 Pap Tests, of which 281 (0.26%) were diagnosed as ASC\u2010H. Tissue follow\u2010up was available in 181 (64%) of these cases, of which 45 (25%) were negative\/cervicitis, 41 (23%) were CIN 1, 36 (20%) were CIN 2 and 59 (32%) were CIN 3. Stratification by age groups showed a higher percentage of high grade (CIN 2+) lesions (65%) in the premenopausal age group as compared with high grade lesion (35%) in the postmenopausal age group, whereas negative\/CIN1 biopsies were more common in postmenopausal (65%) as compared to premenopausal (44%) women. Our data support the use of colposcopy in the management of women with ASC\u2010H on Pap Tests. However, in the older age group, prior HPV\u2010DNA testing may be of benefit to better identify those women at risk for high grade lesions. Diagn. Cytopathol. 2013;41:943\u2013946. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.22982","type":"journal-article","created":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T15:38:49Z","timestamp":1370705929000},"page":"943-946","source":"Crossref","is-referenced-by-count":14,"title":["Clinical significance of atypical squamous cells cannot exclude high grade squamous intraepithelial lesion with histologic correlation\u2014: A 9\u2010Year experience"],"prefix":"10.1002","volume":"41","author":[{"given":"Suzanne M.","family":"Selvaggi","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010225)93:1<16::AID-CNCR9002>3.0.CO;2-A"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332789"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/JM3V-U4HP-W8HJ-68XV"},{"key":"e_1_2_5_6_1","first-page":"335","article-title":"\u201cASCUS, rule out HSIL\u201d: cytologic features, histologic correlates, and human papillomavirus detection","volume":"12","author":"Sherman ME","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10286"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32330-1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21194"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1309\/NPU3WRQCTAB81XLW"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10303"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21844"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20334"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2120"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21387"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20576"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21388"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20497"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980825)84:4<208::AID-CNCR5>3.0.CO;2-I"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1309\/XVB01JQYQNM7MJXU"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23949"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.22982","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.22982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:20:04Z","timestamp":1696612804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.22982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,8]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1002\/dc.22982"],"URL":"https:\/\/doi.org\/10.1002\/dc.22982","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,8]]}}}