{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T10:35:28Z","timestamp":1722249328773},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>The \u201cvacuolated cell pattern\u201d has only been recently described as a distinct morphologic variant of pancreatobiliary adenocarcinoma. Herein, we report the endoscopic ultrasound\u2010guided fine\u2010needle aspiration (EUS\u2010FNA) cytologic features of a case of pancreatic adenocarcinoma with \u201cvacuolated cell pattern\u201d occurring in a 60\u2010year\u2010old man. The aspirate smears and cell block sections from the EUS\u2010FNA of a 23.5 mm hypoechoic pancreatic head mass were highly cellular, showing variably\u2010sized crowded three\u2010dimensional cell clusters, flat sheets, and numerous highly atypical single cells. The background was bloody and showed necrotic debris, but no discernible mucus. The most striking feature of the aspirate was the presence of numerous very large (20\u201350 \u00b5m) vacuoles, occupying the entire cytoplasm, pushing the nuclei to the side and indenting them, that imparted a cribriform appearance to the sheets of neoplastic cells. The non\u2010vacuolated neoplastic cells were large, had abundant dense (squamoid) cytoplasm, irregularly contoured hyperchromatic nuclei, and prominent macronucleoli. Histologic evaluation of the pancreatectomy specimen showed a \u201cvacuolated cell pattern\u201d adenocarcinoma composed of poorly formed glands, solid sheets, and infiltrating single cells with pleomorphic nuclei and large cytoplasmic vacuoles. To our knowledge, this is the first report describing the cytologic features of this rather uncommon morphologic variant of pancreatic adenocarcinoma. Recognition of this morphologic variant of pancreatic adenocarcinoma in ESU\u2010FNA samples allows its differentiation from primary and metastatic signet\u2010ring cell carcinomas. Diagn. Cytopathol. 2014;42:302\u2013307. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.22988","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:32:27Z","timestamp":1392856347000},"page":"302-307","source":"Crossref","is-referenced-by-count":3,"title":["Cytologic features of pancreatic adenocarcinoma with \u201cvacuolated cell pattern.\u201d report of a case diagnosed by endoscopic ultrasound\u2010guided fine\u2010needle aspiration"],"prefix":"10.1002","volume":"42","author":[{"given":"Arbaz","family":"Samad","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical School MMC 609 Mayo Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea B.","family":"Conway","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical School MMC 609 Mayo Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev","family":"Attam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Hepatology and Nutrition Department of Medicine University of Minnesota Medical School MMC 36 Mayo Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Jessurun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical School MMC 609 Mayo Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan E.","family":"Pambuccian","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Medical School MMC 609 Mayo Minneapolis 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