{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:17:22Z","timestamp":1696659442417},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>The Papanicolaou (Pap) test category of \u201clow grade squamous intraepithelial lesion, cannot exclude high grade squamous intraepithelial lesion\u201d (LSIL\u2010H) is not recognized by The Bethesda System but is commonly used. It is essentially an amalgamation of the official LSIL and ASC\u2010H categories. Since these two categories have similar follow\u2010up algorithms, the clinical utility of the combined LSIL\u2010H category is unclear. We have therefore studied follow\u2010up patterns for these three entities in our laboratory to determine the real\u2010world impact of each in our patient population. We searched our pathology database over an 18\u2010month period to find Pap tests (predominantly ThinPrep) interpreted as LSIL\u2010H (137), LSIL (2,189), and ASC\u2010H (101). Like other studies, we found that the discovery rate of high grade dysplasia in biopsies after LSIL\u2010H (31.9%) was similar to ASC\u2010H (35.3%) and was higher than LSIL (7.6%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). In women with no previous history of dysplasia, the frequency of biopsy follow\u2010up after the initial Pap test was significantly higher for LSIL\u2010H (68.3%) than for LSIL (49.6%; <jats:italic>P<\/jats:italic>\u2009=\u20090.0038) and similar to ASC\u2010H (62.3%). We also found that women with an initial negative biopsy or a biopsy positive for low grade dysplasia were more likely to undergo an additional biopsy if the initial Pap test was LSIL\u2010H (36.2%) than if it was LSIL (18.2%; <jats:italic>P<\/jats:italic>\u2009=\u20090.0023). ASC\u2010H (26.9%) had an intermediate rate. In our patient population, the use of the terminology LSIL\u2010H is associated with follow\u2010up biopsy patterns much more similar to ASC\u2010H than to LSIL. Diagn. Cytopathol. 2013;41:960\u2013964. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.22990","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T18:12:08Z","timestamp":1365012728000},"page":"960-964","source":"Crossref","is-referenced-by-count":6,"title":["The impact of LSIL\u2010H terminology on patient follow\u2010up patterns"],"prefix":"10.1002","volume":"41","author":[{"given":"Michael J.","family":"Thrall","sequence":"first","affiliation":[{"name":"The Methodist Hospital Department of Pathology and Genomic Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Galfione","sequence":"additional","affiliation":[{"name":"The University of Texas Department of Dermatology Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora A.","family":"Smith","sequence":"additional","affiliation":[{"name":"The Methodist Hospital Department of Pathology and Genomic Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"The Bethesda system for reporting cervical cytology: Definitions, criteria, and explanatory notes","author":"Solomon D","year":"2005"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-4-7"},{"key":"e_1_2_5_4_1","first-page":"46","article-title":"LSIL\/ASC\u2010H (LSIL\u2010H) in cervicovaginal smear: Histopathological outcomes and clinical significance","volume":"27","author":"Kaygusuz EI","year":"2011","journal-title":"Turk Patoloji Derg"},{"key":"e_1_2_5_5_1","first-page":"462","article-title":"Reporting of \u201cLSIL with ASC\u2010H\u201d on cervicovaginal smears: Is it a valid category to predict cases with HSIL follow\u2010up?","volume":"25","author":"Kir G","year":"2004","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21194"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.060"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_5_10_1","unstructured":"VassarStats. 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