{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:40:50Z","timestamp":1696570850879},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Myxopapillary ependymoma (MPE) is a rare variant of conventional ependymoma found predominantly in the sacrococcygeal region in young adults and characterized by its distinct epithelial and stromal components (WHO grade I designation). MPE with extensive osteolysis is extremely uncommon and only up to 40 cases have been documented. A case is presented here in which imprint smears of a sacral tumor in an 18\u2010year\u2010old man revealed complex papillary structures, small loose clusters, or cord\u2010like structures of bland tumor cells embedded in a myxoid or mucinous background. The tumor cells possessed uniformly round nuclei with a smooth nuclear outline, fine granular chromatin, and small nucleoli. Slender cytoplasmic fibrillary processes and occasional intracytoplasmic vacuoles were observed. A cytologic diagnosis of a MPE was suggested and histochemical and immunohistochemical studies were conducted on formalin\u2010fixed, paraffin\u2010embedded material. Immunohistochemically, the tumor cells showed diffuse and strong membranous and cytoplasmic staining for cytokeratin AE1\/AE3, glial fibrillary protein, and S\u2010100 protein, but negative for epithelial membrane antigen, pan\u2010neuroendocrine markers (i.e., NSE, chromogranin A, synaptophysin), or brachyury. The proliferative index with MIB\u20101 was around 10%. The diagnosis of osteolytic MPE was confirmed based on cytopathologic, histopathological, immunohistochemical results, radiologic findings, and the location of the tumor. We demonstrated here the cytopathological features of osteolytic MPE with emphasis on differential diagnostic considerations. Diagn. Cytopathol. 2014;42:778\u2013783. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23033","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T08:23:13Z","timestamp":1375345393000},"page":"778-783","source":"Crossref","is-referenced-by-count":3,"title":["Cytopathologic characteristics and differential diagnostic considerations of osteolytic myxopapillary ependymoma"],"prefix":"10.1002","volume":"42","author":[{"given":"Toshitetsu","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiji","family":"Haba","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kushida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyuichi","family":"Kadota","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Katsuki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Bando","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10183"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01050071"},{"key":"e_1_2_5_4_1","first-page":"164","article-title":"Myxopapillary ependymoma with extensive sacral destruction: CT and MR findings","volume":"16","author":"Moelleken SM","year":"1992","journal-title":"J Comput Assist Tomogr"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.9.SPINE08968"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00350545"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9482-4"},{"key":"e_1_2_5_8_1","first-page":"363","article-title":"Extradural myxopapillary ependymoma with sacral osteolysis\u2014A case report","volume":"45","author":"Choudhary KK","year":"2002","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050624"},{"key":"e_1_2_5_10_1","first-page":"55","article-title":"Ultrafast Papanicolaou stain. 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