{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:03:30Z","timestamp":1781647410972,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>Liquid\u2010based cytology (LBC) is being increasingly used for body fluid specimens and has improved diagnostic accuracy when compared to conventional smears. We compared the diagnostic accuracy and cellular morphologic features between CellprepPlus\u00ae LBC and ThinPrep\u00ae LBC in effusion cytology.<\/jats:p><jats:p>One hundred and eighty body fluid specimens, consisting of 119 pleural fluid specimens, 59 peritoneal fluid specimens, and 2 pericardial fluid specimens, were obtained from 166 patients. Equal volumes of body fluid from each specimen were used in the CellprepPlus\u00ae and ThinPrep\u00ae preparations. Sensitivity, specificity, and positive and negative predictive values were evaluated. In addition, we selected 16 specimens from patients with metastatic adenocarcinoma, confirmed them by both LBC preparations, and measured the size of the nucleus in the tumor cells in these specimens.<\/jats:p><jats:p>The sensitivity of the CellprepPlus\u00ae and ThinPrep\u00ae methods was 73.1% and 50.0%, respectively. The specificity and positive predictive values were 100% for both LBC methods, and the negative predictive values of the CellprepPlus\u00ae and ThinPrep\u00ae methods were 90.9% and 83.3%, respectively. The average nuclear size of the tumor cells was calculated as 20.87 \u03bcm using the CellprepPlus\u00ae method and 15.08 \u03bcm using the ThinPrep\u00ae method (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><jats:p>The CellprepPlus\u00ae method provided better diagnostic accuracy of effusion cytology compared to the ThinPrep\u00ae method and revealed the characteristic morphological features of tumor cells, including large and hypochromatic nuclei, prominent nucleoli, distinct nuclear membranes, and high cellularity. Diagn. Cytopathol. 2014;42:384\u2013390. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23041","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T18:26:56Z","timestamp":1382725616000},"page":"384-390","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of diagnostic accuracy between CellprepPlus\u00ae and ThinPrep\u00ae liquid\u2010based preparations in effusion cytology"],"prefix":"10.1002","volume":"42","author":[{"given":"Yong\u2010Moon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Yong","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Myoung","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2010Yi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science Chungbuk Health and Science University Cheongwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Suk","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin young","family":"An","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joung\u2010Ho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungbuk National University College of Medicine Heungdeok\u2010gu Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ok\u2010Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Chungbuk National University College of Medicine 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