{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:49:59Z","timestamp":1768279799423,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p>This study assessed the utility and limitations of anal cytology as a screening method for women infected with human papilloma virus (HPV) in the lower genital tract. Furthermore, this study aimed to establish risk factors for pathological anal cytology\/biopsy findings, the prevalence of anatomopathological lesions associated with positive anal brushings, and the frequency of concomitant lesions of the lower genital tract.<\/jats:p><jats:p>A cross\u2010sectional, retrospective, descriptive study in 207 women with HPV\u2010associated lesions of the lower genital tract and 25 women with immunosuppression was carried out. Anal cytology, high resolution anoscopy, and biopsy of suspicious lesions were performed.<\/jats:p><jats:p>In total, 232 anal brushings were performed: 184 (79.3%) were negative, 24 (10.34%) showed atypical squamous cells of undeterminated significance, 18 (7.7%) showed low\u2010grade squamous intraepithelial lesions, and 6 (2.6%) showed high\u2010grade squamous intraepithelial lesion. Cytohistological correlation was obtained for 70 cases. The sensitivity of anal cytology in detecting intraepithelial lesions was 70%, whereas the specificity was 93%. The sensitivity of the method for detecting high\u2010grade lesions (84%) was higher, than that for detecting low\u2010grade lesions (66%). The most frequently associated pathology was vulvar lesion.<\/jats:p><jats:p>It is important to perform anal brushings in women who have had lower genital tract biopsies for HPV\u2010associated lesions due to the high prevalence of anal lesions in such patients. Anal cytology is useful for detecting high\u2010grade lesions but the sensitivity for detecting low\u2010grade lesions is low. It is of the utmost importance to perform high\u2010resolution anoscopy and biopsy in women with suspicious lesions in order to confirm the pathology. Diagn. Cytopathol. 2014;42:396\u2013400. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23050","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T18:38:10Z","timestamp":1382726290000},"page":"396-400","source":"Crossref","is-referenced-by-count":15,"title":["A six\u2010year experience with anal cytology in women with HPV in the lower genital tract: Utility, limitations, and clinical correlation"],"prefix":"10.1002","volume":"42","author":[{"given":"L. H.","family":"Cardinal","sequence":"first","affiliation":[{"name":"Gynecological Pathology Division, Department of Pathology Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Carballo","sequence":"additional","affiliation":[{"name":"Gynecological Pathology Division, Department of Pathology Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. Cabral","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Gynecological Pathology Division, Department of Pathology Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gynecological Pathology Division, Department of Pathology Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d  Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tatti","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d  Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Vighi","sequence":"additional","affiliation":[{"name":"Gynecological Pathology Division, Department of Pathology Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Gynecological Pathology Division, Department of Pathology Hospital de Cl\u00ednicas \u201cJos\u00e9 de San Mart\u00edn,\u201d Universidad de Buenos Aires  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20126"},{"key":"e_1_2_6_3_1","volume-title":"American Cancer Society: Cancer Facts and Figures","year":"2013"},{"key":"e_1_2_6_4_1","first-page":"173","article-title":"Risk factors for abnormal anal cytology in young heterosexual women","volume":"8","author":"Moscicki A\u2010B","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810313"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000181012.62385.4a"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199704150-00004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02051199"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819793d9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.07.066"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-2-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819793d9"},{"key":"e_1_2_6_13_1","first-page":"11","article-title":"The evaluation of anal dysplasia with anal cytology (PAP) followed by high resolution anoscopy (HRA) and biopsy in HIV\u2010infected men","volume":"15","author":"Lee A","year":"2004","journal-title":"Int Conf AIDS"},{"key":"e_1_2_6_14_1","first-page":"408","article-title":"Screening and management of anal dysplasia and anal cancer in HIV\u2010infected patients: A guide for practice","volume":"21","author":"Moran M","year":"2010","journal-title":"JANAC"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200412150-00014"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328333ab8e"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2042-8_8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-2-4"},{"key":"e_1_2_6_19_1","volume-title":"The ABCs of anal rectal cytology","author":"Darragh TM","year":"2004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4994"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646207779949772"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03837.x"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:38:13Z","timestamp":1696639093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,25]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/dc.23050"],"URL":"https:\/\/doi.org\/10.1002\/dc.23050","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,25]]}}}