{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:56:55Z","timestamp":1770267415623,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>This study was performed to determine the associations between human papillomavirus (HPV) infection and cytological changes in the male glans and urethral samples. Two rubbed samples of the glans and distal urethra were collected from 160 patients with urethritis, and the collected cells were placed into preservative solution for liquid\u2010based cytology. DNA was extracted from all samples, and \u03b2\u2010globin gene amplification, HPV\u2010DNA test, and HPV genotyping were performed. After papanicolaou staining of each sample, cytological findings were assessed based on nine non\u2010classic signs, and compared with the results of HPV\u2010DNA test. Among the \u03b2\u2010globin positive samples, HPV (any type) was detected in 33 and 25% of the glans and urethra samples, respectively. High\u2010risk HPV\u2010DNA was detected in 25 and 15% of the glans and urethra samples, respectively. In the glans samples, cytological signs of HPV infection were observed in 17% of low\u2010risk HPV\u2010positive samples and in 58% of high\u2010risk HPV\u2010positive samples. Cytological atypia suspected to indicate penile intraepithelial neoplasia were observed in 17 and 33%, respectively. On the other hand, abnormal cells were observed in 29% of low\u2010risk HPV\u2010positive and 83% of high\u2010risk HPV\u2010positive urethral samples. Cytological atypia suspected to be urethral intraepithelial neoplasia was observed in 29 and 65%, respectively. In situ hybridization demonstrated the presence of HPV\u2010DNA in the morphologically abnormal cells in 31 and 35% of high\u2010risk HPV\u2010positive glans and urethral samples, respectively. Cytological changes similar to cervical intraepithelial neoplasia in females could be detected in the HPV\u2010positive glans and urethral samples. Diagn. Cytopathol. 2014;42:491\u2013497. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23055","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:15:52Z","timestamp":1387584952000},"page":"491-497","source":"Crossref","is-referenced-by-count":5,"title":["Cytological evaluation using liquid\u2010based cytology in the male urogenital tract infected with human papillomavirus"],"prefix":"10.1002","volume":"42","author":[{"given":"Kazuyoshi","family":"Shigehara","sequence":"first","affiliation":[{"name":"Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Sasagawa","sequence":"additional","affiliation":[{"name":"Department of Reproductive and Perinatal Medicine Kanazawa Medical University 1\u20101 Uchinada\u2010machi Daigaku, Kahoku\u2010gun Ishikawa 920\u20100293 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