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Two hundred fifty five patients were evaluated with endometrial imprint cytology during a 29\u2010month period. Endometrial samples freshly resected from women who underwent total abdominal hysterectomy were studied. One hundred twenty six patients had endometrial carcinoma and 129 cases were diagnosed as normal endometrium. The expression of p53 was assessed by immunocytochemistry. Positive staining was correlated with increased surgical\u2010pathological stage, histological grade and lymph node metastases. High expression of p53 staining was significantly more frequent in histological type II than type I endometrial adenocarcinoma. High\u2010grade endometrial carcinoma had higher proportions and stronger intensity compared with low\u2010grade carcinoma. Negative immunostain for p53 protein was found in proliferative, secretory, and atrophic endometrium.<\/jats:p><jats:p>Immunocytochemical findings from p53 stain, in addition to cytomorphologic features, appeared to be useful in the diagnosis and in the postoperative prognosis of endometrial carcinoma in endometrial cytology, especially if combined with other markers. High p53 expression correlates with morphologic features of aggressiveness and the expression pattern of p53 correspond to the expected cyclic\/atrophic pattern in normal endometrium. Diagn. Cytopathol 2014;42:416\u2013422. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23056","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T18:37:40Z","timestamp":1382726260000},"page":"416-422","source":"Crossref","is-referenced-by-count":7,"title":["Expression of p53 in imprint smears of endometrial carcinoma"],"prefix":"10.1002","volume":"42","author":[{"given":"Kosmas","family":"Konstantinos","sequence":"first","affiliation":[{"name":"Department of Cytopathology Anti\u2010cancer Oncological Hospital St. Savvas Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamoulas","family":"Marios","sequence":"additional","affiliation":[{"name":"A' Department of Gynecology Anti\u2010cancer Oncological Hospital St. Savvas Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marouga","family":"Anna","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Athens 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