{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:08:07Z","timestamp":1782598087364,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T00:00:00Z","timestamp":1383782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Stratified mucin\u2010producing intraepithelial lesion (SMILE) of the cervix is a human papilloma virus (HPV) associated high grade intraepithelial columnar cell neoplasm that is thought to arise from the reserve cells of the transformation zone. It is composed of immature stratified cells that display intracytoplasmic mucin and is commonly associated with high grade squamous intraepithelial lesion (HSIL), adenocarcinoma in situ (AIS), and invasive carcinoma. Here, we describe the cytologic features of SMILE and discuss its pitfalls in cervical cytology. A 51\u2010year\u2010old woman was diagnosed with SMILE on a cervical biopsy. Histologically, the dysplastic epithelium showed enlarged nuclei with increased nuclear density and presence of mucin\u2010producing columnar cells throughout its thickness. The slides from the last two Pap tests (ThinPrep) performed on the patient were reviewed and compared with the histology. Cytologically, groups of atypical endocervical glandular cells were seen on both Pap tests. These groups showed mild nuclear crowding, slightly enlarged nuclei, nuclear hyperchromasia, and indistinct nucleoli. The borders of these cell groups were relatively smooth. Original cytologic diagnosis was atypical squamous cells of undetermined significance (ASC\u2010US) in both instances. HPV (Hybrid Capture 2) testing was positive on both occasions. Similar to the histology, cytologic features of SMILE are subtle. The features are not typical for AIS or for HSIL and could easily be misinterpreted as reactive. This report emphasizes that careful review of crowded groups of glandular cells in HPV positive women is absolutely critical. Based on our knowledge, this is the first description of the cytologic features of these lesions. Diagn. Cytopathol. 2014;42:792\u2013797. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23066","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T07:26:31Z","timestamp":1406100391000},"page":"792-797","source":"Crossref","is-referenced-by-count":12,"title":["Cytologic features of stratified mucin producing intraepithelial lesion of the cervix\u2014A case report"],"prefix":"10.1002","volume":"42","author":[{"given":"Abha","family":"Goyal","sequence":"first","affiliation":[{"name":"Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899201"},{"key":"e_1_2_4_3_1","first-page":"23","volume-title":"Tumors of the cervix, vagina and vulva","author":"Silverberg SG","year":"2010"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202684109"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200010000-00012"},{"key":"e_1_2_4_6_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.5858\/133.5.729","article-title":"Current concepts in cervical pathology","volume":"133","author":"Park KJ","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0764-9.00014-7"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.10.012"},{"key":"e_1_2_4_9_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5858\/2004-128-153-DOAISO","article-title":"Detection of adenocarcinoma in situ of the cervix in papanicolaou tests: Comparison of diagnostic accuracy with other high\u2010grade lesions","volume":"128","author":"Renshaw AA","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200008)23:2<127::AID-DC13>3.0.CO;2-I"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.5.653"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330872"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/HL0B-C7Y6-AC77-ND2U"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90143-0"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1309\/N7KCUP0VD59GDJEL"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23639"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.03.044"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000202401.29145.68"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20369"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318183bb0e"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000202401.29145.68"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10061"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23066","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T22:39:33Z","timestamp":1696545573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,7]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1002\/dc.23066"],"URL":"https:\/\/doi.org\/10.1002\/dc.23066","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,7]]}}}