{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:49:44Z","timestamp":1771462184885,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T00:00:00Z","timestamp":1385164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Cystoscopic urine obtained before the resection of low\u2010grade urothelial carcinoma (LGUC), with adequate cytological sampling of the tumor, frequently revealed the presence of three\u2010dimensional cell groups with disordered nuclei and cellular discohesion (3DDD). 936 cystoscopic urine specimens were categorized into five groups: Group 1 (80 specimens) with biopsy\u2010proven LGUC within 6 months of cytologic examination, Group 2 (23 specimens) with biopsy proven LGUC within 6 to 36 months of cytologic examination, Group 3 (527 specimens) with a history of LGUC but no tumor for a period of greater than 3 years, Group 4 (300 specimens) with no association with LGUC, and Group 5 (6 specimens) with urinary lithiasis. Specimens with scant cellularity accounted for 20% of those in Group 1. For 3DDD in detecting LGUC in adequate cystoscopic urine, the sensitivity was 70%, specificity was 94%. Two\u2010 or three\u2010dimensional cell groups with ordered nuclei and\/or cellular non\u2010discohesion were often seen in specimens from Groups 4 or 5. The 3DDD was present in a significant number of cases with concurrent negative cystoscopic findings but also positive LGUC in ensuing follow\u2010up. In these cases, 3DDD with or without tumor identified at concurrent cystoscopy were found to be morphologically similar. Furthermore, the presence of 3DDD in 8% of Group 3 likely represents urothelial dysplasia that is not cystoscopically detectable. The high specificity and sensitivity of 3DDD is demonstrated. These findings are consistent with the decreased cell adhesion and disordered nuclear arrangement of low grade urothelial neoplasia. Diagn. Cytopathol. 2014;42:555\u2013563. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23069","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T09:28:14Z","timestamp":1385371694000},"page":"555-563","source":"Crossref","is-referenced-by-count":10,"title":["Three\u2010dimensional cell groups with disordered nuclei and cellular discohesion (3DDD) are associated with high sensitivity and specificity for cystoscopic urine cytopathological diagnosis of low\u2010grade urothelial neoplasia"],"prefix":"10.1002","volume":"42","author":[{"given":"Kien T","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The Ottawa Hospital and University of Ottawa  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher G.","family":"Ball","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The Ottawa Hospital and University of Ottawa  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Kos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The Ottawa Hospital and University of Ottawa  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric C","family":"Belanger","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The Ottawa Hospital and University of Ottawa  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The Ottawa Hospital and University of Ottawa  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harman","family":"Sekhon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine The Ottawa Hospital and University of Ottawa  Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331605"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19851015)56:8<2041::AID-CNCR2820560826>3.0.CO;2-D"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840401)53:7<1555::AID-CNCR2820530723>3.0.CO;2-G"},{"key":"e_1_2_5_5_1","first-page":"882","article-title":"Accuracy of grading of urothelial carcinoma on urine cytology: An analysis of interobserver and intraobserver agreement","volume":"5","author":"Reid MD","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940901)74:5<1621::AID-CNCR2820740521>3.0.CO;2-E"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333938"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325960"},{"key":"e_1_2_5_9_1","first-page":"110","volume-title":"World classification of tumors","author":"Sauter G","year":"2004"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21743"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.04.019"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1978.tb03031.x"},{"key":"e_1_2_5_13_1","first-page":"67","article-title":"The effect of calculi on transitional epithelium","volume":"3","author":"Ruiter F","year":"1975","journal-title":"A clinical and cytological study. Urol Res"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23069","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:32:43Z","timestamp":1696620763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,23]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1002\/dc.23069"],"URL":"https:\/\/doi.org\/10.1002\/dc.23069","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,23]]}}}