{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:42:07Z","timestamp":1773416527956,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Preoperative cytologic diagnosis of solitary extramedullary plasmacytoma (SEP) presents a challenge to cytopathologists because this tumor rarely occurs as a primary thyroid malignant neoplasm. In this report, we provide the first description of liquid\u2010based cytomorphologic findings of SEP observed on fine\u2010needle aspiration biopsy (FNAB) of the thyroid. A 56\u2010year\u2010old woman with a history of Hashimoto thyroiditis presented with a growing nodule in the thyroid. The liquid\u2010based preparation obtained from FNAB showed numerous dispersed plasmacytoid cells with occasional loosely cohesive aggregates of tumor cells. Cells were round to oval in shape, with eccentrically located nuclei. Hyalinized perinuclear vacuoles were found in the cytoplasm of the tumor cells. Initial cytological findings, including those of immunochemistry using a cell block preparation, were consistent with plasmacytoma. Histopathological examination subsequent to thyroidectomy revealed a plasmacytoma in the thyroid. Plasma cell neoplasms were not concurrently detected in tissues other than the thyroid. On the basis of preoperative FNAB findings, a specific diagnosis of SEP in the thyroid can be difficult because this tumor is rare. Moreover, diagnosis is impeded because SEP in the thyroid resembles other, more common thyroid lesions, including both benign and malignant neoplasms. Careful cytomorphologic examination and supportive studies may be required to fully confirm a diagnosis of SEP. Diagn. Cytopathol. 2014;42:964\u2013969. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23086","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T11:01:24Z","timestamp":1394708484000},"page":"964-969","source":"Crossref","is-referenced-by-count":5,"title":["Liquid\u2010based cytologic findings of solitary extramedullary plasmacytoma in thyroid: A case report identified with fine\u2010needle aspiration cytology"],"prefix":"10.1002","volume":"42","author":[{"given":"Chung Hun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology Chung\u2010Ang University Hospital, Chung\u2010Ang University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Yang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yul Ri","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Suk","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00002"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329029"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325407"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20698"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325513"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325031"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328466"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334009"},{"key":"e_1_2_4_10_1","first-page":"789","article-title":"Fine needle aspiration cytology of extramedullary plasmacytoma","volume":"46","author":"Rege JD","year":"2002","journal-title":"Acta Cytol"},{"key":"e_1_2_4_11_1","first-page":"91","article-title":"Cytological evidence of plasmacytoma of the thyroid","volume":"80","author":"Vailati A","year":"1995","journal-title":"Haematologica"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200011)23:5<354::AID-DC15>3.0.CO;2-7"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1994.4.65"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-002-0015-2"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302253280807"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981025)84:5<295::AID-CNCR5>3.0.CO;2-J"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840020318"},{"key":"e_1_2_4_18_1","first-page":"118","volume-title":"The Bethesda system for reporting thyroid cytopathology","author":"Pitman MB","year":"2010"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-87666-5_6"},{"key":"e_1_2_4_20_1","first-page":"317","article-title":"Morphologic diagnosis of Hurthle cell tumors of the thyroid gland","volume":"37","author":"Vodanovic S","year":"1993","journal-title":"Acta Cytol"},{"key":"e_1_2_4_21_1","first-page":"647","article-title":"Cytopathology of Hurthle cell lesions of the thyroid gland by fine needle aspiration","volume":"25","author":"Kini SR","year":"1981","journal-title":"Acta Cytol"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/100.3.231"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23086","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:44:34Z","timestamp":1696621474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/dc.23086"],"URL":"https:\/\/doi.org\/10.1002\/dc.23086","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}