{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:02:36Z","timestamp":1775257356721,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>We describe a rare case of pancreatic acinar cell carcinoma (ACC) with intraductal growth in a 77\u2010year\u2010old man, which was diagnosed by endoscopic brush cytology. Preoperative imaging revealed an ill\u2010defined mass involving the main pancreatic duct of the body, which was suspected to be an invasive ductal carcinoma. Endoscopic brush cytology showed several thick, small to large clusters of tumor cells. However, a loosely cohesive or individual cell arrangement was more prominent. Singly dispersed naked nuclei, occasionally with crush artifact, were frequently observed. The nuclear contour was smooth and chromatin was finely clumped. The cytoplasm contained many coarse D\u2010PAS\u2010positive granules. Histologically, the tumor expansively invaded to parenchyma and expanded to fill the pancreatic ducts. Ultrastructurally, the tumor cells were less cohesive with scarce tight junctions, and their cytoplasm contained numerous zymogen granules and filamentous inclusions. Although ACCs usually show expansive growth, the incidence of intraductal extension may be higher than previously considered. A few of the characteristic cytomorphological features described here may be useful for differential diagnosis of this tumor from malignant epithelioid neoplasms involving the large pancreatic ducts. Diagn. Cytopathol. 2014;42:321\u2013324. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23087","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:15:11Z","timestamp":1387584911000},"page":"321-324","source":"Crossref","is-referenced-by-count":6,"title":["Brush cytology of acinar cell carcinoma of the pancreas with intraductal growth"],"prefix":"10.1002","volume":"42","author":[{"given":"Yasuhiro","family":"Toyonaga","sequence":"first","affiliation":[{"name":"Department of Pathology Teikyo University, Chiba Medical Center Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Teikyo University, Chiba Medical Center Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology Teikyo University, Chiba Medical Center Ichihara Japan"},{"name":"Department of Molecular Pathology Tokyo Medical University Shinjuku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Koyasu","sequence":"additional","affiliation":[{"name":"Department of Pathology Teikyo University, Chiba Medical Center Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Pathology Teikyo University, Chiba Medical Center Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Pathology Teikyo University, Chiba Medical Center Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_2_4_2_1","article-title":"Tumors of the pancreas. 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