{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:54:38Z","timestamp":1760298878590},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Amyloid deposits are unexpected in salivary gland tumors. A 60\u2010year\u2010old woman presented with a 1.8 cm, slow\u2010growing parotid mass. Both fine\u2010needle aspiration and frozen section were misinterpreted as pleomorphic adenoma. The final pathology was amyloid\u2010rich low grade adenocarcinoma of the parotid gland. The aspirates consisted of three components: mucin, amyloid, and tumor cells. The mucin was unusually thick, stringy, and metachromatic. The amyloid presented as innumerable concretions scattered solitarily or in small jigsaw puzzle\u2010like aggregates, individually wrapped by tumor cells. The tumor cells had bland oval nuclei and scant\u2010to\u2010abundant cytoplasm, arranged in loosely cohesive small sheets. On histology, the tumor cells were arranged in interconnecting monolayered glands of a wide range of size with small patches of cellular regions composed of plump tumor cells. As the luminal mucin and amyloid deposits enlarged, the lining tumor cells became thin and flat. The glandular lumen molded amyloid concretions into different shapes and sizes. Atrophic or pyknotic tumor cells outlined the amyloid concretions with concentric laminations, reminiscent of corpora amylacea. Alcian blue positive luminal mucin, associated with newly formed amyloid, was present in mucinous regions of the tumor. This is the first description of cytologic features of amyloid\u2010rich low grade adenocarcinoma of the parotid and the second case in the pathology literature. The literature of amyloid\u2010rich tumors was reviewed and the implication of the presence of abundant amyloid on the death of tumor cells suggested. Diagn. Cytopathol. 2014;42:798\u2013801. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23099","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T13:42:54Z","timestamp":1392730974000},"page":"798-801","source":"Crossref","is-referenced-by-count":6,"title":["Amyloid\u2010rich low grade adenocarcinoma of the parotid: Fine\u2010needle aspiration cytology with histologic correlations"],"prefix":"10.1002","volume":"42","author":[{"given":"Grace C. H.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William I.","family":"Kuhel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2010Weill Cornell Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"55","article-title":"Ultrafast Papanicolaou stain: An alternative preparation for fine\u2010needle aspiration cytology","volume":"39","author":"Yang GCH","year":"1995","journal-title":"Acta Cytol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(82)80095-6"},{"key":"e_1_2_4_4_1","first-page":"197","volume-title":"Tumors of the salivary glands. 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