{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:03:53Z","timestamp":1779257033316,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>Mixed adenoneuroendocrine carcinoma (MANEC) of ampulla is rare, with only 13 cases reported, and the diagnoses were all based on histology mostly after surgery. We describe two new cases with cytological features of signet ring\u2010cell carcinoma mixed with small\u2010cell carcinoma, and intestinal adenocarcinoma mixed with large\u2010cell neuroendocrine carcinoma. Our cases and literature review demonstrate the higher frequency of periampullary\u2010duodenum subtype in MANEC compared with non\u2010MANEC ampullary carcinomas. In accordance, of the 14 MANEC cases with detailed morphology available, the most common glandular components are intestinal\u2010type carcinoma (6\/14), followed by goblet carcinoid tumor (3\/14), signet ring\u2010cell carcinoma (2\/14), pancreatobiliary\u2010type carcinoma (2\/14), and pancreatic acinar cell carcinoma (1\/14). The intestinal\u2010type carcinoma and goblet carcinoid in MANEC are favorable histological types showing no distant metastasis or mortality (0\/9) during 6\u201336 months follow\u2010up. In contrast, the signet ring cell, pancreatobiliary\u2010type carcinoma, and acinar cell carcinoma are unfavorable with distant metastatic rate and mortality rate of 80% (4\/5) during 3\u201316 months follow\u2010up. The combination of favorable glandular histological types with high\u2010grade neuroendocrine tumors (neuroendocrine carcinoma) has a mortality rate of 0% (0\/3), whereas the combination of unfavorable glandular types with low\u2010grade neuroendocrine tumors (e.g., carcinoid, atypical carcinoid) has a mortality rate of 100% (3\/3). In addition, younger age (&lt;40 years) seems to be associated with high mortality rate of 100% (2\/2). Overall, cytology preparations are able to make the diagnosis of MANEC and distinguish the subcomponents. Disease progression is apparently driven by the carcinomatous component of the tumor. Diagn. Cytopathol. 2014;42:1075\u20131084. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23107","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T14:52:53Z","timestamp":1392821573000},"page":"1075-1084","source":"Crossref","is-referenced-by-count":28,"title":["Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla: Two case reports with review of literature"],"prefix":"10.1002","volume":"42","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"The Department of Pathology and Division of Cytopathology University of Chicago Hospitals Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"DeMay","sequence":"additional","affiliation":[{"name":"The Department of Pathology and Division of Cytopathology University of Chicago Hospitals Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman FT","year":"2010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90187-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90137-T"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90158-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02779365"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/1997\/46751"},{"key":"e_1_2_6_8_1","first-page":"355","article-title":"Adenocarcinoid of the ampulla of Vater","volume":"64","author":"Alex WR","year":"1998","journal-title":"Am Surg"},{"key":"e_1_2_6_9_1","first-page":"670","article-title":"Adenocarcinoide de la ampolla de Vater","volume":"74","author":"Mayol MJ","year":"1998","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.124040"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082006001200012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157974.05397.4f"},{"key":"e_1_2_6_13_1","first-page":"235","article-title":"Collision tumor of the ampulla of Vater: Carcinoid and adenocarcinoma","volume":"99","author":"Marco JF","year":"2007","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_2_6_14_1","first-page":"64","article-title":"Mixed endocrine somatostatinoma of the ampulla of vater associated with a neurofibromatosis type 1: A case report and review of the literature","volume":"11","author":"Deschamps L","year":"2010","journal-title":"JOP"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2009.06.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2012.07.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826399d8"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181a9d49a"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.2385"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.12.008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80337-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2603-0"},{"key":"e_1_2_6_23_1","first-page":"1641","article-title":"The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis","volume":"54","author":"Roh YH","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-170"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:52:38Z","timestamp":1696625558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,19]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/dc.23107"],"URL":"https:\/\/doi.org\/10.1002\/dc.23107","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,19]]}}}