{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:01:30Z","timestamp":1770350490270,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T00:00:00Z","timestamp":1393891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Anal intraepithelial neoplasia (AIN) is associated with HPV infection and can be detected by cytological screening. While conventional exfoliative cytology (CC) is a low\u2010cost and nonaggressive method, liquid\u2010based cytology (LBC) tends to give clearer readings. Although studies of the efficacy of anal cancer screening methods would be of great importance for groups at high risk for AIN, few such studies have been conducted. The aim of the present study was to assess the concordance of CC and LBC in diagnosing anal pre\u2010neoplastic lesions, and to compare cytological results with anoscopy, histopathological, and molecular biology findings. Comparative study involving 33 HIV\u2010positive patients, who underwent anoscopy and biopsy of suspected lesions. Concordance between the two cytology methods was calculated, as were the associations between cytology results and findings from other screening methods. A total of 54.5% of cases were considered AIN\u2010negative by CC and LBC, and concordance between the two methods was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Anoscopy was negative in 15 of the 18 CC\u2010 and LBC\u2010negative cases. CC identified 75% of patients with positive biopsy, while LBC identified 85.71% of these patients. Molecular biology results showed that patients with LSIL tested positive for the highest number of HPV subtypes. The associations between positive biopsy and high grade HPV, HPV 16, and multiple HPV infections were not statistically significant. Conventional and liquid\u2010based cytology are equally effective in screening for anal preneoplastic lesions. Diagn. Cytopathol. 2014;42:840\u2013845. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23130","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T07:33:48Z","timestamp":1393918428000},"page":"840-845","source":"Crossref","is-referenced-by-count":13,"title":["A comparative study between conventional and liquid\u2010based cytology in screening for anal intraepithelial lesions in HIV\u2010positive patients"],"prefix":"10.1002","volume":"42","author":[{"given":"Livia Bravo","family":"Maia","sequence":"first","affiliation":[{"name":"Department of Pathology Hospital Universit\u00e1rio de Bras\u00edlia (HUB) Bras\u00edlia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Cardoso","family":"Marinho","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universit\u00e1rio de Bras\u00edlia (HUB) Bras\u00edlia DF 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