{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:21:48Z","timestamp":1785277308644,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is defined by ETV6\u2010NTRK3 gene fusion. There have been few case reports on the cytopathologic features of MASC to date. We examined the clinicopathological and cytological features of seven cases of MASC defined by RT\u2010PCR analysis of the ETV6\u2010NTRK3 fusion gene. The cases occurred in three men and four women aged between 39 and 68 years, with a mean of 51.6 years. In five of these seven cases, the tumor involved the parotid gland. Histologically, all cases displayed predominantly microcystic patterns, often a mixture of follicular and papillary\u2010cystic structures. All tumors were immunoreactive for mammaglobin, S\u2010100 protein, and vimentin. Available fine\u2010needle aspiration cytology smears were cellular and exhibited many loosely cohesive syncytial clusters or isolated cells. Many histiocytes, some of which contained hemosiderin pigments, and variously shaped mucinous material were evident in the background or within the epithelial clusters. The majority of cases showed small to medium\u2010sized follicular structures with secreted materials. Papillary clusters were occasionally found. Tumor cells exhibited small to medium\u2010sized round to oval nuclei, with a smooth contour and indistinct or small nucleoli, and vacuolated cytoplasm. No tumor cells had obvious intracytoplasmic zymogen granules. It appeared that clusters of small to medium\u2010sized follicular and papillary configurations consisting of bland tumor cells with vacuolated cytoplasm, but lack of intracytoplasmic zymogen granules, in a mucinous or hemosiderin\u2010laden histiocyte\u2010rich background, were a characteristic cytological feature highly suggestive of MASC. Diagn. Cytopathol. 2014;42:846\u2013855. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23139","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T11:32:15Z","timestamp":1393846335000},"page":"846-855","source":"Crossref","is-referenced-by-count":55,"title":["Cytological features of mammary analogue secretory carcinoma of salivary gland: Fine\u2010needle aspiration of seven cases"],"prefix":"10.1002","volume":"42","author":[{"given":"Kayoko","family":"Higuchi","sequence":"first","affiliation":[{"name":"Section of Anatomic Pathology Aizawa Hospital Matsumoto Japan"},{"name":"Department of Aging Biology Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Urano","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology School of Medicine, Fujita Health University Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisuke H.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Oshiro","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Matsubayashi","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiyo","family":"Obikane","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Shimojo","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Shinshu University Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d9efcc"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04232.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318242a5b0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182841554"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00180-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.11.012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPOIE0CZNAT6SQ"},{"key":"e_1_2_6_9_1","first-page":"212","volume-title":"World Health Organization classification of tumours: Pathology and genetics of head and neck tumours","author":"Eveson JW","year":"2005"},{"key":"e_1_2_6_10_1","first-page":"27","volume-title":"General considerations. 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