{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:03:51Z","timestamp":1775624631162,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T00:00:00Z","timestamp":1395964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>This study reviewed the clinical presentation, cytologic findings, and the immunophenotype of 69 Merkel cell carcinoma (MCC) cases sampled by fine\u2010needle aspiration (FNA).<\/jats:p><jats:p>\u2003Demographic and clinical data, the cytology findings, and results of ancillary testing were reviewed.<\/jats:p><jats:p>\u2003Median patient age was 78 years (37\u2212104) with a 1:1.8 female to male ratio. The most common FNA sites sampled included lymph nodes in the neck, the axillary region, the inguinal region and the parotid gland. Most patients had a history of MCC (68%) and\/or non\u2010MCC malignancy (70%).<\/jats:p><jats:p>\u2003The common cytologic pattern was a cellular smear with malignant cells arranged in a dispersed pattern with variable numbers of disorganized groups of cells. Cytoplasm was scant or absent and nuclei showed mild to moderate anisokaryosis, stippled chromatin, inconspicuous nucleoli, and nuclear molding. Numerous apoptotic bodies were often present.<\/jats:p><jats:p>\u2003Cell block samples (28 cases) were usually positive for cytokeratins in a perinuclear dot pattern, including 88% of cases with CK20 positivity. CD56 was the most sensitive (95%) neuroendocrine marker on cell blocks and was also positive with flow cytometry in nine cases tested.<\/jats:p><jats:p>\u2003MCC is most commonly seen in FNA specimens from the head and neck of elderly patients, often with a history of previous skin lesions. Occasional cases present in younger patients and some may be mistaken for other round blue cell tumors, such as lymphoma. CD 56 may be a useful marker in cell block preparations and in flow cytometric analysis of MCC. Diagn. Cytopathol. 2014;42:924\u2013928. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23151","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T16:58:13Z","timestamp":1396025893000},"page":"924-928","source":"Crossref","is-referenced-by-count":24,"title":["Fine\u2010needle aspiration cytology of Merkel cell carcinoma\u2014A review of 69 cases"],"prefix":"10.1002","volume":"42","author":[{"given":"Paul W.","family":"Shield","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences Faculty of Health, Queensland University of Technology Brisbane Queensland Australia"},{"name":"Department of Cytology Sullivan Nicolaides Pathology Taringa Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Crous","sequence":"additional","affiliation":[{"name":"Department of Cytology Sullivan Nicolaides Pathology Taringa Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Neuroendocrine carcinomas.Weedon's skin pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21237"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.00054.x"},{"key":"e_1_2_5_5_1","first-page":"267","article-title":"Neuroendocrine carcinoma (Merkel cell) of the skin. 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