{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:17:24Z","timestamp":1771550244127,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:p>The purpose of this study was to evaluate the clinical significance of Human papillomavirus (HPV) DNA cotesting in Korean women with abnormal Papanicolaou (Pap) smear results based on colposcopic pathology. A total of 1012 women underwent liquid\u2010based Pap smears and hybrid capture II HPV DNA tests followed by colposcopy at the Korea University Hospital from January 2007 to May 2012. Of these women, 832 women were included in this retrospective study. The mean patient age was 45.4\u2009\u00b1\u200913.7 years (range:15\u201380). The distribution of Pap smear results was normal (4.7%), atypical squamous cells of uncertain significance (ASCUS) (42.1%), low\u2010grade squamous intraepithelial lesion (26.8%), ASC\u2010H (7.0%), and high\u2010grade squamous intraepithelial lesion (HSIL) (19.5%). In women with ASCUS, none of the 87 HPV\u2010negative had \u2265cervical intraepithelial neoplasia (CIN2) (P\u2009&lt;\u20090.001). In women with ASC\u2010H, only one out of 17 HPV\u2010negative vs. 14 out of 41 HPV\u2010positive had \u2265CIN2 (P\u2009=\u20090.025). In patients with HSIL, 54.5% of HPV\u2010negative had \u2265CIN2, as compared to 80.8% of HPV\u2010positive with \u2265CIN2 (P\u2009=\u20090.039). Patients were further analyzed by age groups: &lt;30 and \u226530 years. In HPV\u2010negative women, there was a significant difference in the ratio of \u2265CIN2 (30.8% &lt;30 vs. 4.5% \u226530, P\u2009=\u20090.005). When the HPV DNA test was negative in women \u226530, the risk of \u2265CIN2 was significantly lower (P\u2009&lt;\u20090.001). HPV DNA cotesting in women with ASCUS and ASC\u2010H furnish healthcare providers with informative data. There is a lower proportion of \u2265CIN2 in HPV\u2010negative women and a higher proportion of \u2265CIN2 in HPV\u2010positive. When HPV data were further evaluated by age group, the risk of \u2265CIN2 was lower in HPV\u2010negative women, especially in women \u226530. Diagn. Cytopathol. 2014;42:1058\u20131062. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23173","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T05:14:48Z","timestamp":1400044488000},"page":"1058-1062","source":"Crossref","is-referenced-by-count":8,"title":["Clinical significance of <scp>HPV DNA<\/scp> cotesting in <scp>Korean<\/scp> women with <scp>ASCUS<\/scp> or <scp>ASC\u2010H<\/scp>"],"prefix":"10.1002","volume":"42","author":[{"given":"Sanghoon","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yun","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nak Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"GLOBOCAN Cancer Fact Sheet\u2010 globocan2012.Available at:http:\/\/www.iarc.fr\/en\/media\u2010centre\/pr\/2013\/pdfs\/pr223_E.pdf"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61416-0"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053284"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072142"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPTGD94EVRSJCG"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2013.03.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.050"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2010.0103"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-12-201206190-00424"},{"key":"e_1_2_5_11_1","volume-title":"Initial management of abnormal cervical cytology (Pap test) and HPV test in adult and adolescent females","author":"Institute for Clinical System Improvement","year":"2013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2013.24.2.186"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5858\/134.3.331","article-title":"Practices of participants in the College of American Pathologists interlaboratory comparison program in cervicovaginal cytology, 2006","volume":"134","author":"Eversole GM","year":"2010","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22487"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21844"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22982"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPYK60BZRNNAHQ"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.06.018"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.021642-0"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2009.24.4.579"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01709.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70188-7"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:52:17Z","timestamp":1696625537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,14]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/dc.23173"],"URL":"https:\/\/doi.org\/10.1002\/dc.23173","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,14]]}}}