{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:18:46Z","timestamp":1761988726445},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T00:00:00Z","timestamp":1400889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fine needle aspiration cytology (FNAC) of TB lymphadenitis (TBL) in HIV shows four different patterns, which may be reflective of immune status. We hypothesize that the CD<jats:sub>4<\/jats:sub> counts, a marker of immunologic status, correlates with FNAC morphology of TBL. This study was undertaken to compare the mean CD<jats:sub>4<\/jats:sub> counts across the different cytology patterns and to correlate the CD<jats:sub>4<\/jats:sub> counts with FNAC patterns in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty newly diagnosed HIV patients with TBL on FNAC (10 in each pattern) were selected by convenient sampling based on inclusion exclusion criteria. The CD<jats:sub>4<\/jats:sub> counts were obtained in these patients. Its correlation with different FNAC patterns was assessed using SPSS version 16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of covariance showed significant difference in the mean CD<jats:sub>4<\/jats:sub> counts between all the four patterns [F (374), df (3), <jats:italic>P<\/jats:italic>\u2010value\u2009=\u20090.000]. Spearman's correlation analysis showed significant correlation of CD<jats:sub>4<\/jats:sub> counts with the FNAC patterns (correlation coefficient of 0.967; <jats:italic>P<\/jats:italic>\u2010value of 0.01) with pattern 1 having low CD<jats:sub>4<\/jats:sub> counts and pattern 4 having high CD<jats:sub>4<\/jats:sub> counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CD<jats:sub>4<\/jats:sub> counts show significant correlation with FNAC patterns of TBL in HIV patients. Pattern 1, suggestive of poor immunological response (chiefly necrosis, occasional ill defined granuloma, AFB 3+) had low CD<jats:sub>4<\/jats:sub> counts, while pattern 4, suggestive of good immunological response (well defined granuloma, no necrosis and AFB 1+), had high CD<jats:sub>4<\/jats:sub> counts. Thus FNAC patterns may be used to predict the CD<jats:sub>4<\/jats:sub> counts in HIV patients where CD<jats:sub>4<\/jats:sub> facilities are not available or vice versa. Diagn. Cytopathol. 2015;43:16\u201320. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23177","type":"journal-article","created":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T15:31:00Z","timestamp":1400945460000},"page":"16-20","source":"Crossref","is-referenced-by-count":8,"title":["Correlation of CD<sub>4<\/sub> counts with the FNAC patterns of tubercular lymphadenitis in patients with HIV: A cross sectional pilot study"],"prefix":"10.1002","volume":"43","author":[{"given":"Joseph Sushil","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pathology and Department of Biochemistry, St. John's Medical College and Hospital Koramangala Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Kumari S","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Biochemistry, St. John's Medical College and Hospital Koramangala Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usha","family":"Kini","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Biochemistry, St. John's Medical College and Hospital Koramangala Bangalore Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327869"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10059"},{"key":"e_1_2_5_4_1","first-page":"4","article-title":"FNAC of peripheral lymphnodes in HIV\u2010positive patients","volume":"1","author":"Kumarguru","year":"2009","journal-title":"Sci Med"},{"key":"e_1_2_5_5_1","first-page":"111","article-title":"Acid \u2013 fast staining patterns and their correlation with HIV positivity","volume":"49","author":"Kumar S","year":"2005","journal-title":"Acta 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