{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T11:17:38Z","timestamp":1696677458427},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico), Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Screening for anal cancer using cytology has not been considered in immunocompetent women. The aim of this study was to identify cytological atypia and human papillomavirus (HPV) DNA in intra\u2010anal specimens from human immunodeficiency virus (HIV)\u2010negative women with and without genital HPV lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a cross\u2010sectional analysis of 142 women who were negative for the HIV: 80 with genital lesions that were associated with HPV and 62 without HPV\u2010induced lesions. The women were evaluated at the Federal University of Cear\u00e1 from October 2011 to June 2012. The statistical analysis included the Fisher exact test and the odds ratio (CI 95%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Atypical anal cytology was observed in 24 (29.3%) patients in the study group and in 11 (17.8%) patients in the control group. In cases with at least two sites of HPV\u2010associated lesions, 12 (41.4%) presented atypical cytology (P = 0.0220; OR = 2.7621, 1.1579\u20136.5889). When the practice of anal sex was evaluated, atypical cytology was observed in 22\/43 (34%) [P = 0.0214; OR = 2.519, 1.146\u20135.534]. HPV DNA was detected in 17\/27 (63%) cases with at least two sites of lesions (P = 0.0293, OR = 2.4855, 1.0960\u20135.6367). In the 33 cases who presented positive HPV DNA test results, the liquid\u2010based cytology results were atypical (P = 0.0212, OR = 2.8, 1.1665\u20136.7208).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the results, liquid\u2010based cytology may be used to detect intra\u2010anal lesions, especially among women who have a history of anal intercourse or who have genital HPV\u2010associated lesions at multiple sites. Diagn. Cytopathol. 2015;43:360\u2013365. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23238","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T05:03:14Z","timestamp":1416891794000},"page":"360-365","source":"Crossref","is-referenced-by-count":5,"title":["Liquid\u2010based cytology and HPV DNA testing using intra\u2010anal specimens from HIV\u2010negative women with and without genital HPV\u2010induced lesions"],"prefix":"10.1002","volume":"43","author":[{"suffix":"Jr.","given":"Jos\u00e9","family":"Eleut\u00e9rio","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, Faculty of Medicine Federal University of Cear\u00e1 Fortaleza Brazil"},{"name":"Department of Pathology, Faculty of Medicine Federal University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Givanildo Carneiro","family":"Ben\u00edcio","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Federal University of Cear\u00e1 Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo C\u00e9sar","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology State University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Katherine Silveira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal University of Rio Grande do Norte Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata M\u00edrian Nunes","family":"Eleut\u00e9rio","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology Prof. Eleut\u00e9rio Laboratory Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise 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