{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:57:50Z","timestamp":1760299070350},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T00:00:00Z","timestamp":1421884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sebaceous carcinomas (SBCs) are aggressive tumors with the potential to cause great morbidity and mortality. Poorly\u2010differentiated tumors may at times pose challenges for the correct diagnosis. p40, a new antibody that targets a short isoform of p63 has been shown as a promising squamous cell marker. In this study, we sought to evaluate cytomorphological features of SBC and p40 expression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 29 previously diagnosed cases of SBCs including fine\u2010needle aspirates and histopathology specimens from various sites were reviewed and studied for p40 expression. p40 nuclear expression was semi\u2010quantitatively assessed. Adequate positive and negative controls of non\u2010small cell lung carcinoma were taken for comparison. Expression pattern of normal sebaceous glands was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 29 cases, 13 (44.8%) were from the periocular region. The most common extraocular site was parotid gland. Morphologically tumors were categorized into well\u2010 and poorly\u2010differentiated varieties based on extent of sebaceous differentiation. p40 positivity was seen in all cases of cytology aspirates and histology sections with similar intensity. No difference in percentage positivity of cells was recorded in well\u2010 and poorly\u2010differentiated tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>p40 can be a valuable marker when evaluating tumors with possible sebaceous differentiation. Although p40 expression in SBCs is not as useful for the differential diagnosis that includes poorly\u2010differentiated squamous cell carcinoma, this study, for the first time in the literature, highlights an important observation that p40 can be utilized as a marker for sebaceous lineage. Diagn. Cytopathol. 2015;43:456\u2013461. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23250","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T06:32:33Z","timestamp":1421908353000},"page":"456-461","source":"Crossref","is-referenced-by-count":12,"title":["Cytomorphology of sebaceous carcinoma with analysis of p40 antibody expression"],"prefix":"10.1002","volume":"43","author":[{"given":"Deepali","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi 110029 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep R.","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi 110029 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehar C.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi 110029 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkateswaran K.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences New Delhi 110029 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2004.12.008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.07.031"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200408000-00006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP89LYTPNVOBAP"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31820a4837"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.12.009"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.01.005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31823815d3"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.173"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.045"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12105"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.061"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0342-OA"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2008.02.007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850901)56:5<1163::AID-CNCR2820560533>3.0.CO;2-A"},{"key":"e_1_2_5_18_1","first-page":"320","article-title":"Sebaceous glands in salivary gland tissue","volume":"98","author":"Linhartova A","year":"1974","journal-title":"Arch Pathol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199911)21:5<340::AID-DC9>3.0.CO;2-C"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22892"},{"key":"e_1_2_5_21_1","volume-title":"Pathology of Unusual Malignant Cutaneous Tumors","author":"Wolfe III JT","year":"1985"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23250","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:58:52Z","timestamp":1695542332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,22]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1002\/dc.23250"],"URL":"https:\/\/doi.org\/10.1002\/dc.23250","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,22]]}}}