{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:39:44Z","timestamp":1787683184765,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>A new case of soft tissue myoepithelial carcinoma (MEC) with rhabdoid\u2010like differentiation is presented including cytologic, histopathologic, immunohistochemical, and molecular biologic features. A 45\u2010year\u2010old woman was admitted to the Hospital with nodular mass involving the lower part of the abdominal wall. Fine\u2010needle aspiration cytology showed a round cell tumor with abundant cytoplasm in the myxoid background. The nuclei were uniform, round to ovoid, with finely distributed chromatin, nucleoli, and pale, vacuolated, or eosinophilic cytoplasm with rhabdoid\u2010like appearance resembling a soft tissue malignant rhabdoid tumor. The surgically removed tumor was poorly demarcated, yellow, soft, and myxoid. The histopathology revealed sheets of poorly differentiated round malignant cells with focal myxoid stroma and rhabdoid\u2010like morphology. Immunohistochemistry showed positivity for CK (AE1\/AE3), EMA, S100, vimentin, CD99, and SMA; however desmin, CD34, and gliofibrilar acid protein (GFAP) were negative. Tumor cells revealed loss of INI1 expression. The<jats:italic>EWSR1<\/jats:italic>gene rearrangement was detected by fluorescence in situ hybridization (FISH), but molecular biology failed to detect<jats:italic>EWSR1\/ETS, EWSR1\/NR4A3, EWSR1\/DDIT3, EWSR1\/ATF1, EWSR1\u2010POU5F1, EWSR1\/ZNF444, EWSR1\u2010PBX1<\/jats:italic>gene fusions. The final diagnosis was soft tissue malignant myoepithelioma with rhabdoid changes and<jats:italic>EWSR1<\/jats:italic>gene rearrangement. The differential diagnosis included soft tissue malignant rhabdoid tumor, cellular extraskeletal myxoid chondrosarcoma, proximal epithelioid sarcoma, and other soft tissue tumor with<jats:italic>EWSR1<\/jats:italic>rearrangement. To our knowledge, this is the first case of MEC with rhabdoid features and description of fine\u2010needle aspiration cytology. Diagn. Cytopathol. 2015;43:421\u2013426. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23259","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T05:57:23Z","timestamp":1424325443000},"page":"421-426","source":"Crossref","is-referenced-by-count":21,"title":["Soft tissue myoepithelial carcinoma with rhabdoid\u2010like features and<scp><i>EWSR<\/i><\/scp><i>1<\/i>rearrangement: Fine needle aspiration cytology with histologic correlation"],"prefix":"10.1002","volume":"43","author":[{"given":"Isidro","family":"Machado","sequence":"first","affiliation":[{"name":"Pathology Department Instituto Valenciano De Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"L\u00f3pez\u2010Soto","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Enrique Cabrera (Nacional) Ciudad Habana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Rubio","sequence":"additional","affiliation":[{"name":"Molecular Biology Department Instituto Valenciano De Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Navarro","sequence":"additional","affiliation":[{"name":"Molecular Biology Department Medical School, University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Llombart\u2010Bosch","sequence":"additional","affiliation":[{"name":"Pathology Department Medical School, University of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000039"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-317"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1335-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1240-0"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.08.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.108"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2012.e53"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324978"},{"key":"e_1_2_6_10_1","article-title":"Rhabdoid variant of myoepithelial carcinoma, with EWSR1 rearrangement: Expanding the spectrum of EWSR1\u2010rearranged myoepithelial Tumors","author":"Thway K","journal-title":"Head Neck Pathol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12058"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822b325b"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000038"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21470"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23140"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.4103\/0377-4929.91534","article-title":"Cytomorphology and immunohistochemistry of extrarenal rhabdoid tumor: A case report with review of literature","volume":"54","author":"Jain M","year":"2011","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326646"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20242"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513810600908388"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23259","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T08:50:58Z","timestamp":1717750258000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,19]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1002\/dc.23259"],"URL":"https:\/\/doi.org\/10.1002\/dc.23259","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,19]]}}}